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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide characterization of the routes to pluripotency
|
|---|---|
| Published in |
Nature, December 2014
|
| DOI | 10.1038/nature14046 |
| Pubmed ID | |
| Authors |
Samer M. I. Hussein, Mira C. Puri, Peter D. Tonge, Marco Benevento, Andrew J. Corso, Jennifer L. Clancy, Rowland Mosbergen, Mira Li, Dong-Sung Lee, Nicole Cloonan, David L. A. Wood, Javier Munoz, Robert Middleton, Othmar Korn, Hardip R. Patel, Carl A. White, Jong-Yeon Shin, Maely E. Gauthier, Kim-Anh Lê Cao, Jong-Il Kim, Jessica C. Mar, Nika Shakiba, William Ritchie, John E. J. Rasko, Sean M. Grimmond, Peter W. Zandstra, Christine A. Wells, Thomas Preiss, Jeong-Sun Seo, Albert J. R. Heck, Ian M. Rogers, Andras Nagy |
| Abstract |
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the reprograming process. To address this gap in knowledge, we generated extensive transcriptomic, epigenomic and proteomic data sets describing the reprogramming routes leading from mouse embryonic fibroblasts to induced pluripotency. Through integrative analysis, we reveal that cells transition through distinct gene expression and epigenetic signatures and bifurcate towards reprogramming transgene-dependent and -independent stable pluripotent states. Early transcriptional events, driven by high levels of reprogramming transcription factor expression, are associated with widespread loss of histone H3 lysine 27 (H3K27me3) trimethylation, representing a general opening of the chromatin state. Maintenance of high transgene levels leads to re-acquisition of H3K27me3 and a stable pluripotent state that is alternative to the embryonic stem cell (ESC)-like fate. Lowering transgene levels at an intermediate phase, however, guides the process to the acquisition of ESC-like chromatin and DNA methylation signature. Our data provide a comprehensive molecular description of the reprogramming routes and is accessible through the Project Grandiose portal at http://www.stemformatics.org. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 32% |
| Australia | 3 | 14% |
| United Kingdom | 2 | 9% |
| Spain | 1 | 5% |
| Denmark | 1 | 5% |
| Japan | 1 | 5% |
| Italy | 1 | 5% |
| France | 1 | 5% |
| Unknown | 5 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 55% |
| Scientists | 8 | 36% |
| Science communicators (journalists, bloggers, editors) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 623 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 1% |
| United Kingdom | 4 | <1% |
| Australia | 2 | <1% |
| France | 2 | <1% |
| Germany | 2 | <1% |
| Spain | 2 | <1% |
| Turkey | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 7 | 1% |
| Unknown | 591 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 164 | 26% |
| Researcher | 149 | 24% |
| Student > Master | 73 | 12% |
| Student > Bachelor | 44 | 7% |
| Professor > Associate Professor | 40 | 6% |
| Other | 113 | 18% |
| Unknown | 40 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 287 | 46% |
| Biochemistry, Genetics and Molecular Biology | 169 | 27% |
| Medicine and Dentistry | 38 | 6% |
| Neuroscience | 14 | 2% |
| Engineering | 10 | 2% |
| Other | 49 | 8% |
| Unknown | 56 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 99. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#434,284
of 26,017,215 outputs
Outputs from Nature
#20,820
of 99,074 outputs
Outputs of similar age
#5,031
of 374,318 outputs
Outputs of similar age from Nature
#331
of 950 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 99,074 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.3. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 950 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.