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Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages

Overview of attention for article published in Nanomedicine: Nanotechnology, Biology and Medicine, March 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 1,520)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
6 news outlets
twitter
1 X user
facebook
1 Facebook page
googleplus
13 Google+ users

Citations

dimensions_citation
56 Dimensions

Readers on

mendeley
54 Mendeley
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Title
Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages
Published in
Nanomedicine: Nanotechnology, Biology and Medicine, March 2014
DOI 10.1016/j.nano.2014.02.010
Pubmed ID
Authors

Kirsten M. Pondman, Martin Sobik, Annapurna Nayak, Anthony G. Tsolaki, Anne Jäkel, Emmanuel Flahaut, Silke Hampel, Bennie ten Haken, Robert B. Sim, Uday Kishore

Abstract

Carbon nanotubes (CNTs) have promised a range of applications in biomedicine. Although influenced by the dispersants used, CNTs are recognized by the innate immune system, predominantly by the classical pathway of the complement system. Here, we confirm that complement activation by the CNT used continues up to C3 and C5, indicating that the entire complement system is activated including the formation of membrane-attack complexes. Using recombinant forms of the globular regions of human C1q (gC1q) as inhibitors of CNT-mediated classical pathway activation, we show that C1q, the first recognition subcomponent of the classical pathway, binds CNTs via the gC1q domain. Complement opsonisation of CNTs significantly enhances their uptake by U937 cells, with concomitant downregulation of pro-inflammatory cytokines and up-regulation of anti-inflammatory cytokines in both U937 cells and human monocytes. We propose that CNT-mediated complement activation may cause recruitment of cellular infiltration, followed by phagocytosis without inducing a pro-inflammatory immune response.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 30%
Researcher 10 19%
Student > Bachelor 7 13%
Student > Master 5 9%
Student > Doctoral Student 4 7%
Other 6 11%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 20%
Pharmacology, Toxicology and Pharmaceutical Science 6 11%
Immunology and Microbiology 5 9%
Chemistry 4 7%
Materials Science 4 7%
Other 14 26%
Unknown 10 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2022.
All research outputs
#754,717
of 25,394,764 outputs
Outputs from Nanomedicine: Nanotechnology, Biology and Medicine
#30
of 1,520 outputs
Outputs of similar age
#7,066
of 235,955 outputs
Outputs of similar age from Nanomedicine: Nanotechnology, Biology and Medicine
#3
of 23 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,520 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.