| Title |
Adapting to insulin resistance in obesity: role of insulin secretion and clearance
|
|---|---|
| Published in |
Diabetologia, December 2017
|
| DOI | 10.1007/s00125-017-4511-0 |
| Pubmed ID | |
| Authors |
Sang-Hee Jung, Chan-Hee Jung, Gerald M. Reaven, Sun H. Kim |
| Abstract |
The aim of this study was to quantify the relative contributions of increased insulin secretion rate (ISR) and decreased insulin clearance rate (ICR) in the compensatory hyperinsulinaemia characteristic of insulin-resistant individuals without diabetes. Obese (BMI ≥30 kg/m2) individuals without diabetes (n = 91) were identified from a registry of volunteers. Volunteers underwent the following measurements: oral glucose tolerance; insulin resistance (steady-state plasma glucose [SSPG] concentration during the insulin suppression test [IST]); ISR (using the graded glucose infusion test [GGIT]); and ICR (using the IST and GGIT). Participants were stratified into tertiles based on SSPG concentration: SSPG-1(insulin-sensitive); SSPG-2 (intermediate); and SSPG-3 (insulin-resistant). There were no differences in BMI and waist circumference among the SSPG tertiles. Serum alanine aminotransferase concentrations were higher in the SSPG-2 and SSPG-3 groups compared with the SSPG-1 group (p = 0.02). Following an oral glucose challenge, there was a progressive increase in the total integrated insulin response from the most insulin-sensitive to the most insulin-resistant tertiles (p < 0.001). Following intravenous glucose, the SSPG-3 group had significantly greater integrated glucose (median [interquartile range], 32.9 [30.8-36.3] mmol/l × h) and insulin responses (1711 [1476-2223] mmol/l × h) compared with the SSPG-1 group (30.3 [28.8-32.9] mmol/l × h, p = 0.04, and 851 [600-1057] pmol/l × h, p < 0.001, respectively). Furthermore, only the SSPG-3 group had significant changes in both ISR and ICR (p < 0.001). In the SSPG-2 group, only the ICR was significantly decreased compared with the SSPG-1 group. Therefore, ICR progressively declined during the IST with increasing insulin resistance (SSPG-1, 0.48 [0.41-0.59]; SSPG-2, 0.43 [0.39-0.50]; SSPG-3, 0.34 [0.31-0.40]). While both increases in ISR and decreases in ICR compensate for insulin resistance, decreases in ICR may provide the first adaptation to decreased insulin sensitivity. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 5 | 14% |
| Spain | 4 | 11% |
| United States | 4 | 11% |
| France | 3 | 9% |
| United Kingdom | 2 | 6% |
| Denmark | 2 | 6% |
| Germany | 1 | 3% |
| Netherlands | 1 | 3% |
| Belgium | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 63% |
| Scientists | 10 | 29% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 18% |
| Student > Bachelor | 13 | 15% |
| Student > Master | 8 | 9% |
| Researcher | 8 | 9% |
| Other | 5 | 6% |
| Other | 10 | 12% |
| Unknown | 26 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 28% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Nursing and Health Professions | 6 | 7% |
| Business, Management and Accounting | 2 | 2% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 9 | 11% |
| Unknown | 32 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#1,885,325
of 25,058,309 outputs
Outputs from Diabetologia
#1,028
of 5,334 outputs
Outputs of similar age
#41,469
of 449,896 outputs
Outputs of similar age from Diabetologia
#30
of 70 outputs
Altmetric has tracked 25,058,309 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,334 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one has done well, scoring higher than 80% of its peers.
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We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.