| Title |
Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks
|
|---|---|
| Published in |
Biotechnology Techniques, July 2014
|
| DOI | 10.1007/s10529-014-1621-3 |
| Pubmed ID | |
| Authors |
Maite Sabalza, Paul Christou, Teresa Capell |
| Abstract |
Molecular pharming is a cost-effective platform for the production of recombinant proteins in plants. Although the biopharmaceutical industry still relies on a small number of standardized fermentation-based technologies for the production of recombinant proteins there is now a greater awareness of the advantages of molecular pharming particularly in niche markets. Here we discuss some of the technical, economic and regulatory barriers that constrain the clinical development and commercialization of plant-derived pharmaceutical proteins. We also discuss strategies to increase productivity and product quality/homogeneity. The advantages of whole plants should be welcomed by the industry because this will help to reduce the cost of goods and therefore expand the biopharmaceutical market into untapped sectors. |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| South Africa | 1 | <1% |
| Australia | 1 | <1% |
| Egypt | 1 | <1% |
| Unknown | 141 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 17% |
| Student > Master | 25 | 17% |
| Student > Bachelor | 25 | 17% |
| Student > Ph. D. Student | 23 | 16% |
| Other | 7 | 5% |
| Other | 20 | 14% |
| Unknown | 20 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 41% |
| Biochemistry, Genetics and Molecular Biology | 35 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Medicine and Dentistry | 4 | 3% |
| Engineering | 4 | 3% |
| Other | 12 | 8% |
| Unknown | 26 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2014.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Biotechnology Techniques
#2,353
of 2,762 outputs
Outputs of similar age
#174,936
of 239,409 outputs
Outputs of similar age from Biotechnology Techniques
#11
of 26 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,762 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,409 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.