| Title |
Binding of a natural anthocyanin inhibitor to influenza neuraminidase by mass spectrometry
|
|---|---|
| Published in |
Analytical & Bioanalytical Chemistry, June 2013
|
| DOI | 10.1007/s00216-013-7068-x |
| Pubmed ID | |
| Authors |
Kavya Swaminathan, Jeffrey C. Dyason, Andrea Maggioni, Mark von Itzstein, Kevin M. Downard |
| Abstract |
The binding of a natural anthocyanin to influenza neuraminidase has been studied employing mass spectrometry and molecular docking. Derived from a black elderberry extract, cyanidin-3-sambubiocide has been found to be a potent inhibitor of sialidase activity. This study reveals the molecular basis for its activity for the first time. The anthocyanin is shown by parallel experimental and computational approaches to bind in the so-called 430-cavity in the vicinity of neuraminidase residues 356-364 and 395-432. Since this antiviral compound binds remote from Asp 151 and Glu 119, two residues known to regulate neuraminidase resistance, it provides the potential for the development of a new class of antivirals against the influenza virus without this susceptibility. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 19% |
| Researcher | 7 | 16% |
| Student > Bachelor | 7 | 16% |
| Professor | 3 | 7% |
| Professor > Associate Professor | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 16% |
| Biochemistry, Genetics and Molecular Biology | 6 | 14% |
| Agricultural and Biological Sciences | 5 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Other | 8 | 19% |
| Unknown | 9 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2023.
All research outputs
#732,190
of 25,373,627 outputs
Outputs from Analytical & Bioanalytical Chemistry
#30
of 9,618 outputs
Outputs of similar age
#5,521
of 210,217 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#1
of 74 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,618 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.