Title |
Orale Vitamin-B12-Substitution bei funikulärer Myelose
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Published in |
Der Nervenarzt, October 2006
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DOI | 10.1007/s00115-006-2137-4 |
Pubmed ID | |
Authors |
J. Wellmer, K.-U. Sturm, W. Herrmann, J. Hoever, T. Klockgether, M. Linnebank |
Abstract |
Vitamin B12 deficiency due to malnutrition or malabsorption may lead to pernicious anemia and neurological disorders. Although randomized prospective studies have shown that pernicious anemia can be safely treated with oral vitamin B12 even in the absence of intrinsic factor, it is still common practice to treat patients with neurological symptoms with intramuscular cyancobalamin injections. We report the successful oral treatment of subacute combined degeneration of the spinal cord in a 24-year-old woman closely monitored clinically with MRI and plasma levels of vitamin B12, homocysteine, and methylmalonic acid. We suggest monitored oral substitution therapy as first-line therapy for neurological disorders related to vitamin B12 deficiency. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 4 | 100% |
Demographic breakdown
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Student > Postgraduate | 1 | 25% |
Student > Doctoral Student | 1 | 25% |
Student > Master | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 50% |
Biochemistry, Genetics and Molecular Biology | 1 | 25% |
Unknown | 1 | 25% |