| Title |
Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients
|
|---|---|
| Published in |
Critical Care, December 2014
|
| DOI | 10.1186/s13054-014-0701-z |
| Pubmed ID | |
| Authors |
Peter JM Weijs, Wilhelmus GPM Looijaard, Albertus Beishuizen, Armand RJ Girbes, Heleen M Oudemans-van Straaten |
| Abstract |
IntroductionEarly protein and energy feeding in critically ill patients is heavily debated and early protein feeding hardly studied.MethodsA prospective database with mixed medical-surgical critically ill patients with prolonged mechanical ventilation (>72 hours) and measured energy expenditure was used in this study. Logistic regression analysis was used to analyse the relation between admission day-4 protein intake group (with cutoffs 0.8, 1.0, and 1.2 g/kg), energy overfeeding (ratio energy intake/measured energy expenditure¿>¿1.1), and admission diagnosis of sepsis with hospital mortality after adjustment for APACHE II (Acute Physiology and Chronic Health Evaluation II) score.ResultsA total of 843 patients were included. Of these, 117 had sepsis. Of the 736 non-septic patients 307 were overfed. Mean day-4 protein intake was 1.0 g/kg pre-admission weight per day and hospital mortality was 36%. In the total cohort, day-4 protein intake group (odds ratio (OR) 0.85; 95% confidence interval (CI) 0.73 to 0.99; P¿=¿0.047), energy overfeeding (OR 1.62; 95%CI 1.07 to 2.44; P¿=¿0.022), and sepsis (OR 1.77; 95%CI 1.18 to 2.65; P¿=¿0.005) were independent risk factors for mortality besides APACHE II score. In patients with sepsis or energy overfeeding, day-4 protein intake was not associated with mortality. For non-septic, non-overfed patients (n¿=¿419), mortality decreased with higher protein intake group: 37% for <0.8 g/kg, 35% for 0.8 to 1.0 g/kg, 27% for 1.0 to 1.2 g/kg, and 19% for ¿1.2 g/kg (P¿=¿0.033). For these, a protein intake level of ¿1.2 g/kg was significantly associated with lower mortality (OR 0.42, 95%CI 0.21 to 0.83, P¿=¿0.013).ConclusionsIn non-septic critically ill patients, early high protein intake was associated with lower mortality and early energy overfeeding with higher mortality. In septic patients early high protein intake had no beneficial effect on mortality. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 19% |
| United States | 7 | 17% |
| Comoros | 1 | 2% |
| Spain | 1 | 2% |
| India | 1 | 2% |
| Canada | 1 | 2% |
| Sweden | 1 | 2% |
| Ecuador | 1 | 2% |
| Malaysia | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 20 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 67% |
| Practitioners (doctors, other healthcare professionals) | 6 | 14% |
| Scientists | 5 | 12% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 301 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 297 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 48 | 16% |
| Researcher | 38 | 13% |
| Other | 31 | 10% |
| Student > Ph. D. Student | 23 | 8% |
| Student > Doctoral Student | 18 | 6% |
| Other | 62 | 21% |
| Unknown | 81 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 131 | 44% |
| Nursing and Health Professions | 36 | 12% |
| Biochemistry, Genetics and Molecular Biology | 8 | 3% |
| Agricultural and Biological Sciences | 7 | 2% |
| Engineering | 4 | 1% |
| Other | 22 | 7% |
| Unknown | 93 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2023.
All research outputs
#1,163,264
of 25,630,321 outputs
Outputs from Critical Care
#942
of 6,595 outputs
Outputs of similar age
#14,807
of 362,844 outputs
Outputs of similar age from Critical Care
#4
of 128 outputs
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