| Title |
Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial
|
|---|---|
| Published in |
Diabetologia, November 2017
|
| DOI | 10.1007/s00125-017-4502-1 |
| Pubmed ID | |
| Authors |
Michael Gejl, Albert Gjedde, Birgitte Brock, Arne Møller, Eelco van Duinkerken, Hanne L. Haahr, Charlotte T. Hansen, Pei-Ling Chu, Kirstine L. Stender-Petersen, Jørgen Rungby |
| Abstract |
The aim of this randomised, crossover trial was to compare cognitive functioning and associated brain activation patterns during hypoglycaemia (plasma glucose [PG] just below 3.1 mmol/l) and euglycaemia in individuals with type 1 diabetes mellitus. In this patient-blinded, crossover study, 26 participants with type 1 diabetes mellitus attended two randomised experimental visits: one hypoglycaemic clamp (PG 2.8 ± 0.2 mmol/l, approximate duration 55 min) and one euglycaemic clamp (PG 5.5 mmol/l ± 10%). PG levels were maintained by hyperinsulinaemic glucose clamping. Cognitive functioning was assessed during hypoglycaemia and euglycaemia conditions using a modified version of the digit symbol substitution test (mDSST) and control DSST (cDSST). Simultaneously, regional cerebral blood flow (rCBF) was measured in pre-specified brain regions by six H215O-positron emission tomographies (PET) per session. Working memory was impaired during hypoglycaemia as indicated by a statistically significantly lower mDSST score (estimated treatment difference [ETD] -0.63 [95% CI -1.13, -0.14], p = 0.014) and a statistically significantly longer response time (ETD 2.86 s [7%] [95% CI 0.67, 5.05], p = 0.013) compared with euglycaemia. During hypoglycaemia, mDSST task performance was associated with increased activity in the frontal lobe regions, superior parietal lobe and thalamus, and decreased activity in the temporal lobe regions (p < 0.05). Working memory activation (mDSST - cDSST) statistically significantly increased blood flow in the striatum during hypoglycaemia (ETD 0.0374% [95% CI 0.0157, 0.0590], p = 0.002). During hypoglycaemia (mean PG 2.9 mmol/l), working memory performance was impaired. Altered performance was associated with significantly increased blood flow in the striatum, a part of the basal ganglia implicated in regulating motor functions, memory, language and emotion. NCT01789593, clinicaltrials.gov FUNDING: This study was funded by Novo Nordisk. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 21% |
| United States | 4 | 11% |
| Spain | 3 | 8% |
| Serbia | 1 | 3% |
| Sweden | 1 | 3% |
| Italy | 1 | 3% |
| Saudi Arabia | 1 | 3% |
| Netherlands | 1 | 3% |
| El Salvador | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 13 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 66% |
| Scientists | 7 | 18% |
| Practitioners (doctors, other healthcare professionals) | 4 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 7 | 11% |
| Researcher | 7 | 11% |
| Other | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 18 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 19% |
| Nursing and Health Professions | 9 | 14% |
| Psychology | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Neuroscience | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 20 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2018.
All research outputs
#1,469,606
of 24,041,016 outputs
Outputs from Diabetologia
#802
of 5,207 outputs
Outputs of similar age
#34,234
of 445,655 outputs
Outputs of similar age from Diabetologia
#23
of 68 outputs
Altmetric has tracked 24,041,016 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.9. This one has done well, scoring higher than 84% of its peers.
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