| Title |
Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based screening program
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, December 2014
|
| DOI | 10.1007/s10549-014-3208-z |
| Pubmed ID | |
| Authors |
Xavier Castells, Laia Domingo, Josep María Corominas, Isabel Torá-Rocamora, María Jesús Quintana, Marisa Baré, Carmen Vidal, Carmen Natal, Mar Sánchez, Francina Saladié, Joana Ferrer, Mar Vernet, Sonia Servitja, Ana Rodríguez-Arana, Marta Roman, Josep Alfons Espinàs, María Sala |
| Abstract |
Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 2% |
| Unknown | 96 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 18% |
| Researcher | 13 | 13% |
| Other | 11 | 11% |
| Professor > Associate Professor | 8 | 8% |
| Student > Bachelor | 7 | 7% |
| Other | 15 | 15% |
| Unknown | 26 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 46% |
| Nursing and Health Professions | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Agricultural and Biological Sciences | 2 | 2% |
| Unspecified | 2 | 2% |
| Other | 9 | 9% |
| Unknown | 30 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2014.
All research outputs
#18,386,678
of 22,774,233 outputs
Outputs from Breast Cancer Research and Treatment
#3,713
of 4,653 outputs
Outputs of similar age
#256,782
of 354,732 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#39
of 51 outputs
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