Title |
Relationship of EMAST and Microsatellite Instability Among Patients with Rectal Cancer
|
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Published in |
Journal of Gastrointestinal Surgery, September 2010
|
DOI | 10.1007/s11605-010-1340-6 |
Pubmed ID | |
Authors |
Bikash Devaraj, Aaron Lee, Betty L. Cabrera, Katsumi Miyai, Linda Luo, Sonia Ramamoorthy, Temitope Keku, Robert S. Sandler, Kathleen L. McGuire, John M. Carethers |
Abstract |
Elevated microsatellite instability at selected tetranucleotide repeats (EMAST) is a genetic signature identified in 60% of sporadic colon cancers and may be linked with heterogeneous expression of the DNA mismatch repair (MMR) protein hMSH3. Unlike microsatellite instability-high (MSI-H) in which hypermethylation of hMLH1 occurs followed by multiple susceptible gene mutations, EMAST may be associated with inflammation and subsequent relaxation of MMR function with the biological consequences not known. We evaluated the prevalence of EMAST and MSI in a population-based cohort of rectal cancers, as EMAST has not been previously determined in rectal cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 32% |
Researcher | 9 | 29% |
Student > Master | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Professor | 1 | 3% |
Other | 3 | 10% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 32% |
Agricultural and Biological Sciences | 9 | 29% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Nursing and Health Professions | 1 | 3% |
Computer Science | 1 | 3% |
Other | 3 | 10% |
Unknown | 3 | 10% |