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The role of mutations in epigenetic regulators in myeloid malignancies

Overview of attention for article published in Immunological Reviews, December 2014
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Title
The role of mutations in epigenetic regulators in myeloid malignancies
Published in
Immunological Reviews, December 2014
DOI 10.1111/imr.12246
Pubmed ID
Authors

Brittany A. Woods, Ross L. Levine

Abstract

Over the past decade, genomic studies have identified a number of novel and recurrent somatic mutations that affect epigenetic patterning in patients with myeloid malignancies, including myeloproliferative neoplasms, myelodysplastic syndrome, and acute myeloid leukemia. Many of these mutations occur in genes with established roles in the regulation and maintenance of DNA methylation and/or chromatin modifications in hematopoietic stem/progenitor cells. Subsequent genetic and functional studies have revealed that these mutations affect epigenetic patterning in myeloid diseases. In this review, we discuss historical and recent studies implicating epigenetic modifiers in the development and evolution of the various myeloid malignancies and discuss how this knowledge has and will lead to future clinical and biologic insights.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 182 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Unknown 179 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 39 21%
Student > Ph. D. Student 32 18%
Student > Bachelor 21 12%
Student > Master 14 8%
Other 10 5%
Other 34 19%
Unknown 32 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 55 30%
Medicine and Dentistry 42 23%
Agricultural and Biological Sciences 26 14%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Chemistry 4 2%
Other 15 8%
Unknown 36 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2016.
All research outputs
#14,553,484
of 24,417,958 outputs
Outputs from Immunological Reviews
#1,796
of 2,244 outputs
Outputs of similar age
#184,082
of 363,783 outputs
Outputs of similar age from Immunological Reviews
#10
of 13 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,244 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,783 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.