Title |
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans
|
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Published in |
Marine Drugs, May 2014
|
DOI | 10.3390/md12052937 |
Pubmed ID | |
Authors |
Christina Viegelmann, Jennifer Parker, Thengtheng Ooi, Carol Clements, Gráinne Abott, Louise Young, Jonathan Kennedy, Alan D. W. Dobson, RuAngelie Edrada-Ebel |
Abstract |
The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations. |
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Mendeley readers
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