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Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

Overview of attention for article published in Marine Drugs, May 2014
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Title
Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans
Published in
Marine Drugs, May 2014
DOI 10.3390/md12052937
Pubmed ID
Authors

Christina Viegelmann, Jennifer Parker, Thengtheng Ooi, Carol Clements, Gráinne Abott, Louise Young, Jonathan Kennedy, Alan D. W. Dobson, RuAngelie Edrada-Ebel

Abstract

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5a,8a-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
United Kingdom 1 2%
United States 1 2%
Unknown 54 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 16%
Student > Master 8 14%
Student > Ph. D. Student 7 12%
Researcher 6 11%
Student > Doctoral Student 3 5%
Other 7 12%
Unknown 17 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Chemistry 8 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Biochemistry, Genetics and Molecular Biology 5 9%
Medicine and Dentistry 4 7%
Other 2 4%
Unknown 19 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2015.
All research outputs
#15,312,760
of 22,774,233 outputs
Outputs from Marine Drugs
#1,957
of 3,546 outputs
Outputs of similar age
#133,612
of 227,096 outputs
Outputs of similar age from Marine Drugs
#42
of 64 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,546 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,096 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.