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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors
|
|---|---|
| Published in |
Nature Communications, December 2014
|
| DOI | 10.1038/ncomms6750 |
| Pubmed ID | |
| Authors |
Preston S.K. Ng, Raphael Böhm, Lauren E. Hartley-Tassell, Jason A. Steen, Hui Wang, Samuel W. Lukowski, Paula L. Hawthorne, Ann E.O. Trezise, Peter J. Coloe, Sean M. Grimmond, Thomas Haselhorst, Mark von Itzstein, Adrienne W. Paton, James C. Paton, Michael P. Jennings |
| Abstract |
Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). In humans, this enzyme is inactive and only Neu5Ac is produced. Ferrets are susceptible to human-adapted IAV strains and have been the dominant animal model for IAV studies. Here we show that ferrets, like humans, do not synthesize Neu5Gc. Genomic analysis reveals an ancient, nine-exon deletion in the ferret CMAH gene that is shared by the Pinnipedia and Musteloidia members of the Carnivora. Interactions between two human strains of IAV with the sialyllactose receptor (sialic acid-α2,6Gal) confirm that the type of terminal sialic acid contributes significantly to IAV receptor specificity. Our results indicate that exclusive expression of Neu5Ac contributes to the susceptibility of ferrets to human-adapted IAV strains. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| Australia | 2 | 29% |
| India | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 43% |
| Members of the public | 3 | 43% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 23% |
| Student > Ph. D. Student | 13 | 19% |
| Student > Doctoral Student | 7 | 10% |
| Student > Bachelor | 6 | 9% |
| Professor > Associate Professor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 20% |
| Biochemistry, Genetics and Molecular Biology | 13 | 19% |
| Immunology and Microbiology | 9 | 13% |
| Chemistry | 9 | 13% |
| Medicine and Dentistry | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 14 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2024.
All research outputs
#907,959
of 25,202,494 outputs
Outputs from Nature Communications
#14,994
of 55,730 outputs
Outputs of similar age
#10,783
of 343,378 outputs
Outputs of similar age from Nature Communications
#171
of 742 outputs
Altmetric has tracked 25,202,494 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,730 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,378 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 742 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.