Title |
Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades
|
---|---|
Published in |
Head & Neck, June 2015
|
DOI | 10.1002/hed.23942 |
Pubmed ID | |
Authors |
Angela Hong, C Soon Lee, Deanna Jones, Anne-Sophie Veillard, Mei Zhang, Xiaoying Zhang, Robert Smee, June Corry, Sandro Porceddu, Christopher Milross, Michael Elliott, Jonathan Clark, Barbara Rose |
Abstract |
Background This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal cancer (OSCC) over the last two decades. Methods The HPV status of 515 OSCC diagnosed between 1987-2010 was determined by HPV E6-targeted multiplex PCR and p16 immunohistochemistry. Results The HPV positivity rate increased from 20.2% (1987-1995) to 63.5% (2006-2010). Among HPV-positive OSCC over the study period, the median age increased from 55.4 years to 59.8 years (p=0.004) and there was a trend of an increasing proportion of never smoker (19.2% to 34.0%). The use of radiation therapy in patients with HPV-positive oropharyngeal cancer increased from 26.9% to 68.1% (p=0.007) and we also observed a trend of improved outcomes. Conclusions Our data show a rising prevalence of HPV-positive OSCC in Australia over the last two decades. These patients with HPV-positive OSCC are now presenting at an older age and about one third have never smoked. This article is protected by copyright. All rights reserved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 20% |
Student > Postgraduate | 5 | 10% |
Student > Bachelor | 5 | 10% |
Other | 4 | 8% |
Researcher | 4 | 8% |
Other | 12 | 24% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 42% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Nursing and Health Professions | 2 | 4% |
Engineering | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 3 | 6% |
Unknown | 16 | 32% |