| Title |
Baseline neutrophil-lymphocyte ratio (≥2.8) as a prognostic factor for patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation
|
|---|---|
| Published in |
Radiation Oncology, December 2014
|
| DOI | 10.1186/s13014-014-0295-2 |
| Pubmed ID | |
| Authors |
Lijun Shen, Hui Zhang, Liping Liang, Guichao Li, Ming Fan, Yongxin Wu, Ji Zhu, Zhen Zhang |
| Abstract |
BackgroundThe neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response and may predict the clinical outcome in some cancers, such as head and neck cancer and gastric cancer. However, the value of this ratio is variable in different cancers. Studies of the relationship between NLR and both survival and response to chemoradiation have been limited with respect to locally advanced rectal cancer.Methods and materialsFrom 2006 to 2011, 199 consecutive locally advanced rectal cancer patients who were treated with neoadjuvant chemoradiation in the Shanghai Cancer Center were enrolled and analysed retrospectively. Tumor response was evaluated by pathological findings. The baseline total white blood cell count (WBC) and the neutrophil, lymphocyte, platelet counts were recorded. The neutrophil-lymphocyte ratio (NLR) and the relationship with clinical outcomes such as overall survival (OS) and disease-free survival (DFS) was analyzed.ResultsWith ROC analysis, the baseline NLR value was found to significantly predict prognosis in terms of OS well in locally advanced rectal cancer patients. A multivariate analysis identified that a cut-off value of NLR¿¿¿2.8 could be used as an independent factor to indicate decreased OS (HR, 2.123; 95%CI, 1.140-3.954; P¿=¿0.018). NLR¿¿¿2.8 was also associated with worse DFS in univariate analysis (HR, 1.662; 95%CI, 1.037-2.664; P¿=¿0.035), though it was not significant in the multivariate analysis (HR, 1.363; 95%CI, 0.840-2.214; P¿=¿0.210). There was no observed significant correlation of mean value of NLR to the response to neoadjuvant chemoradiation. The mean NLR in the ypT0-2 N0 group was 2.68¿±¿1.38, and it was 2.77¿±¿1.38 in the ypT3-4/N+ group, with no statistical significance (P¿=¿0.703). The mean NLR in the TRG 0¿1 group was 2.68¿±¿1.42, and it was 2.82¿±¿1.33 in the TRG 2¿3 group with no statistical significance (P¿=¿0.873).ConclusionsAn elevated baseline NLR is a valuable and easily available prognostic factor for OS in addition to tumor response after neoadjuvant therapy. Baseline NLR could be a useful candidate factor for stratifying patients and making treatment decisions in locally advanced rectal cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 21% |
| Student > Bachelor | 9 | 19% |
| Student > Doctoral Student | 6 | 13% |
| Researcher | 6 | 13% |
| Student > Master | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 6 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 66% |
| Agricultural and Biological Sciences | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 8 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2014.
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#20,705,128
of 23,305,591 outputs
Outputs from Radiation Oncology
#1,706
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#299,030
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Outputs of similar age from Radiation Oncology
#73
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