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Attention Score in Context
| Title |
Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents
|
|---|---|
| Published in |
Journal of Child Psychology & Psychiatry, December 2017
|
| DOI | 10.1111/jcpp.12843 |
| Pubmed ID | |
| Authors |
Barbara Ruggeri, Christine Macare, Serena Stopponi, Tianye Jia, Fabiana M. Carvalho, Gabriel Robert, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean Luc Martinot, Marie‐Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos‐Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Henrik Walter, Robert Whelan, Wolfgang H. Sommer, Georgy Bakalkin, Roberto Ciccocioppo, Gunter Schumann, the IMAGEN consortium |
| Abstract |
Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Canada | 1 | 25% |
| France | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 13% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 6 | 9% |
| Student > Ph. D. Student | 6 | 9% |
| Professor | 4 | 6% |
| Other | 8 | 12% |
| Unknown | 27 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 9 | 13% |
| Neuroscience | 9 | 13% |
| Medicine and Dentistry | 3 | 4% |
| Agricultural and Biological Sciences | 3 | 4% |
| Nursing and Health Professions | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 35 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2019.
All research outputs
#17,313,103
of 25,411,814 outputs
Outputs from Journal of Child Psychology & Psychiatry
#2,907
of 3,285 outputs
Outputs of similar age
#279,430
of 445,011 outputs
Outputs of similar age from Journal of Child Psychology & Psychiatry
#41
of 44 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,285 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,011 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.