| Title |
Neuropathology of iatrogenic Creutzfeldt–Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology
|
|---|---|
| Published in |
Acta Neuropathologica, November 2017
|
| DOI | 10.1007/s00401-017-1791-x |
| Pubmed ID | |
| Authors |
Charles Duyckaerts, Véronique Sazdovitch, Kunie Ando, Danielle Seilhean, Nicolas Privat, Zehra Yilmaz, Laurène Peckeu, Elodie Amar, Emmanuel Comoy, Aleksandra Maceski, Sylvain Lehmann, Jean-Pierre Brion, Jean-Philippe Brandel, Stéphane Haïk |
| Abstract |
Abeta deposits and tau pathology were investigated in 24 French patients that died from iatrogenic Creutzfeldt-Jakob disease after exposure to cadaver-derived human growth hormone (c-hGH) in the 1980s. Abeta deposits were found only in one case that had experienced one of the longest incubation periods. Three cases had also intracellular tau accumulation. The analysis of 24 batches of c-hGH, produced between 1974 and 1988, demonstrated for the first time the presence of Abeta and tau contaminants in c-hGH (in 17 and 6 batches, respectively). The incubation of prion disease was shorter in the French patients than the incubation times reported in two previously published British series. We interpreted the low incidence of Abeta in this French series as a consequence of the shorter incubation period observed in France, as compared to that observed in the United Kingdom. This concept suggested that a mean incubation period for the development of detectable Abeta deposits would be longer than 18 years after the first exposure. Moreover, we hypothesized that tau pathology might also be transmissible in humans. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 16% |
| Student > Ph. D. Student | 12 | 15% |
| Professor | 9 | 11% |
| Student > Bachelor | 7 | 9% |
| Student > Master | 7 | 9% |
| Other | 10 | 13% |
| Unknown | 21 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 27% |
| Agricultural and Biological Sciences | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Medicine and Dentistry | 5 | 6% |
| Immunology and Microbiology | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 39. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2024.
All research outputs
#1,052,065
of 25,470,300 outputs
Outputs from Acta Neuropathologica
#157
of 2,532 outputs
Outputs of similar age
#23,555
of 446,210 outputs
Outputs of similar age from Acta Neuropathologica
#4
of 31 outputs
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