| Title |
Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy
|
|---|---|
| Published in |
Methods in Cell Science, December 2014
|
| DOI | 10.1007/s10616-014-9830-0 |
| Pubmed ID | |
| Authors |
Mohamed L. Salem, Ahmed S. El-Badawy, Zihai Li |
| Abstract |
Cancer stem cells (CSCs) need to survive cancer treatments with a specific end goal to provide new, more differentiated, metastatic-prone cancerous cells. This happens through diverse signals delivered within the tumor microenvironment where ample evidence indicates that altered developmental signaling pathways play an essential role in maintaining CSCs and accordingly the survival and the progression of the tumor itself. This review summarizes findings on the immunobiological properties of CSCs as compared with cancerous non-stem cells involving the expression of immunological molecules, cytokines and tumor antigens as well as the roles of the Notch, Wnt and Hedgehog pathways in the brain, breast and colon CSCs. We concluded that if CSCs are the main driving force behind tumor support and growth then understanding the molecular mechanisms and the immunological properties directing these cells for immune tolerance is of great clinical significance. Such knowledge will contribute to designing better targeted therapies that could prevent tumor recurrence and accordingly significantly improve cancer treatments and patient survival. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Luxembourg | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 34% |
| Researcher | 5 | 14% |
| Student > Postgraduate | 3 | 9% |
| Student > Master | 3 | 9% |
| Student > Bachelor | 3 | 9% |
| Other | 4 | 11% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 26% |
| Biochemistry, Genetics and Molecular Biology | 8 | 23% |
| Immunology and Microbiology | 4 | 11% |
| Agricultural and Biological Sciences | 3 | 9% |
| Psychology | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 7 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2015.
All research outputs
#19,941,677
of 25,368,786 outputs
Outputs from Methods in Cell Science
#842
of 1,026 outputs
Outputs of similar age
#244,408
of 347,646 outputs
Outputs of similar age from Methods in Cell Science
#11
of 18 outputs
Altmetric has tracked 25,368,786 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,026 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.