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Mendeley readers
Attention Score in Context
| Title |
B7-H4 Expression by Nonhematopoietic Cells in the Tumor Microenvironment Promotes Antitumor Immunity
|
|---|---|
| Published in |
Cancer Immunology Research, February 2015
|
| DOI | 10.1158/2326-6066.cir-14-0113 |
| Pubmed ID | |
| Authors |
Ramtin Rahbar, Albert Lin, Magar Ghazarian, Helen-Loo Yau, Sangeetha Paramathas, Philipp A. Lang, Anita Schildknecht, Alisha R. Elford, Carlos Garcia-Batres, Bernard Martin, Hal K. Berman, Wey L. Leong, David R. McCready, Michael Reedijk, Susan J. Done, Naomi Miller, Bruce Youngson, Woong-Kyung Suh, Tak W. Mak, Pamela S. Ohashi |
| Abstract |
The B7 family plays a critical role in both positive and negative regulation of immune responses by engaging a variety of receptors on lymphocytes. Importantly, blocking co-inhibitory molecules using antibodies specific for CTLA-4 and PD-1 enhances tumor immunity in a subset of patients. Therefore, it is critical to understand the role of different B7 family members since they may be suitable therapeutic targets. B7-H4 is another member that inhibits T-cell function, and it is also up-regulated on a variety of tumors and has been proposed to promote tumor growth. Here we investigate the role of B7-H4 in tumor development and show that B7-H4 expression inhibits tumor growth in two mouse models. Furthermore, we show that B7-H4 expression is required for antitumor immune responses in a mouse model of mammary tumorigenesis. We found the expression levels of B7-H4 correlate with MHC class I expression in both mouse and human samples. We show that IFNγ up-regulates B7-H4 expression on mouse embryo fibroblasts and that the up-regulation of B7-H4 on tumors is dependent on T cells. Notably, breast cancer patients with increased B7-H4 expression show a prolonged time to recurrence. These studies demonstrate a positive role for B7-H4 in promoting antitumor immunity. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Unknown | 73 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 27% |
| Student > Master | 9 | 12% |
| Student > Ph. D. Student | 8 | 11% |
| Professor > Associate Professor | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 15 | 20% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 30% |
| Immunology and Microbiology | 19 | 26% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Agricultural and Biological Sciences | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 13 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#7,890,886
of 23,923,788 outputs
Outputs from Cancer Immunology Research
#844
of 1,446 outputs
Outputs of similar age
#109,330
of 357,757 outputs
Outputs of similar age from Cancer Immunology Research
#22
of 27 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,446 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.0. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,757 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.