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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Biological variation of high sensitivity cardiac troponin-T in stable dialysis patients: implications for clinical practice
|
|---|---|
| Published in |
Clinical Chemistry and Laboratory Medicine, December 2014
|
| DOI | 10.1515/cclm-2014-0838 |
| Pubmed ID | |
| Authors |
Magid A. Fahim, Andrew D. Hayen, Andrea R. Horvath, Goce Dimeski, Amanda Coburn, Ken-Soon Tan, David W. Johnson, Jonathan C. Craig, Scott B. Campbell, Carmel M. Hawley |
| Abstract |
Abstract Background: Changes in high sensitivity cardiac troponin-T (hs-cTnT) concentrations may reflect either acute myocardial injury or biological variation. Distinguishing between these entities is essential to accurate diagnosis, however, the biological variation of hs-cTnT in dialysis population is currently unknown. We sought to estimate the within- and between-person coefficients of variation of hs-cTnT in stable dialysis patients, and derive the critical difference between measurements needed to exclude biological variation with 99% confidence. Methods: Fifty-five prevalent haemo- and peritoneal-dialysis patients attending two metropolitan hospitals were assessed on 10 consecutive occasions; weekly for 5 weeks then monthly for 4 months. Assessments were conducted at the same dialysis cycle time-point and entailed hs-cTnT testing, clinical review, electrocardiography, and bioimpedance spectroscopy. Patients were excluded if they developed clinical or physiological instability. Results: In total 137 weekly and 114 monthly hs-cTnT measurements from 42 stable patients were analysed. Respective between- and within-person coefficients of variation were 83% and 7.9% for weekly measurements, and 79% and 12.6% for monthly measurements. Within-person variation was unaffected by dialysis modality or cardiac co-morbidity. The bidirectional 99% reference change value was -25% and +33% for weekly measurements, and -37% and +58% for monthly measurements. Conclusions: The between-person variation of hs-cTnT in the dialysis population is markedly greater than within-person variation indicating that hs-cTnT testing is best applied in this population using a relative change strategy. An increase of 33% or a reduction of 25% in serial hs-cTnT concentrations measured at weekly intervals excludes change due to analytical and biological variation alone with 99% confidence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 22% |
| Other | 4 | 17% |
| Student > Master | 3 | 13% |
| Student > Ph. D. Student | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Other | 2 | 9% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 52% |
| Nursing and Health Professions | 3 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Sports and Recreations | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 5 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2014.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Clinical Chemistry and Laboratory Medicine
#1,791
of 2,902 outputs
Outputs of similar age
#267,339
of 360,089 outputs
Outputs of similar age from Clinical Chemistry and Laboratory Medicine
#15
of 47 outputs
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So far Altmetric has tracked 2,902 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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