| Title |
Current Concepts of Epigenetics and Its Role in Periodontitis
|
|---|---|
| Published in |
Current Oral Health Reports, November 2017
|
| DOI | 10.1007/s40496-017-0156-9 |
| Pubmed ID | |
| Authors |
Lena Larsson |
| Abstract |
The focus of this review is to provide an overview of the recent findings on the role of epigenetic mechanisms in periodontal disease, including disease susceptibility, progression, and as potential treatment options. The findings on the influence of oral pathogens on epigenetic regulation of pathogen recognition receptors, such as Toll-like receptors, as well as pro-inflammatory cytokines suggest an important role for epigenetics in the regulation of the host immune response. Recent studies also show that the epigenetic pattern in periodontitis lesions differ from that of healthy and gingivitis tissue. In addition, these patterns differ between tissues in the same individual. Research is also indicating a role for both DNA methylation and histone acetylation on cells osteogenic differentiation and bone regeneration. Knowledge of epigenetic pattern in periodontal diseases may add not only to the knowledge of susceptibility of the disease but may also be a diagnostic tool to identify patients at risk to develop the severe form of periodontitis. In addition, recent research within gene therapy and tissue engineering indicate a role for epigenetics also to improve regeneration of periodontal tissues. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 21 | 23% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Postgraduate | 10 | 11% |
| Student > Bachelor | 6 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 28 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 43% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Immunology and Microbiology | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Nursing and Health Professions | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 28 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#19,951,180
of 25,382,440 outputs
Outputs from Current Oral Health Reports
#62
of 91 outputs
Outputs of similar age
#249,936
of 342,377 outputs
Outputs of similar age from Current Oral Health Reports
#2
of 2 outputs
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