Title |
Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy
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Published in |
BMC Genomics, December 2014
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DOI | 10.1186/1471-2164-15-1144 |
Pubmed ID | |
Authors |
Paul O’Reilly, Csaba Ortutay, Grainne Gernon, Enda O’Connell, Cathal Seoighe, Susan Boyce, Luis Serrano, Eva Szegezdi |
Abstract |
Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction between genes whose protein products potentially influence each other, which limits its power to identify molecular wiring of tumour cells dictating response to a drug. Due to the fact that signal transduction pathways are not linear and highly interlinked, the biological response they drive may be better described by the relative amount of their components and their functional relationships than by their individual, absolute expression. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 32% |
Student > Bachelor | 4 | 14% |
Student > Master | 4 | 14% |
Student > Ph. D. Student | 3 | 11% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 14% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Engineering | 4 | 14% |
Agricultural and Biological Sciences | 4 | 14% |
Computer Science | 4 | 14% |
Medicine and Dentistry | 2 | 7% |
Other | 5 | 18% |
Unknown | 5 | 18% |