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The significance of diminished sTWEAK and P-selectin content in platelets of patients with pulmonary arterial hypertension

Overview of attention for article published in Cytokine, December 2017
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Title
The significance of diminished sTWEAK and P-selectin content in platelets of patients with pulmonary arterial hypertension
Published in
Cytokine, December 2017
DOI 10.1016/j.cyto.2017.11.014
Pubmed ID
Authors

Remigiusz Kazimierczyk, Piotr Błaszczak, Krzysztof Kowal, Małgorzata Jasiewicz, Małgorzata Knapp, Anna Szpakowicz, Katarzyna Ptaszyńska-Kopczyńska, Bożena Sobkowicz, Ewa Waszkiewicz, Ryszard Grzywna, Włodzimierz J Musial, Karol A Kamiński

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by proliferative changes in pulmonary arteries. There is growing evidence suggesting that soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and P-selectin could be involved in PAH development and progression. Here we investigate whether circulating platelets may be a source of sTWEAK and contribute to diminished availability of sTWEAK and P-selectin in PAH patients. We have prospectively enrolled two independent study groups of stable patients with confirmed PAH and age matched controls: derivation (10 PAH; 15 controls) and validation (20 PAH; 12 controls). P-selectin and sTWEAK concentrations were measured in platelet-poor plasma and platelet lysate. To avoid procedural bias, in each group we employed different protocols for platelet isolation. Consistently, both in derivation and validation groups PAH patients presented significantly lower sTWEAK content in platelets than control group with no significant differences in plasma levels. Similarly, patients presented comparable to controls plasma P-selectin concentrations and lower concentration in platelet lysate. Kaplan-Meier analysis revealed that patients with low platelet sTWEAK/total protein concentration ratio had more frequently detoriation of PAH in the follow-up (16.51 ± 3.32 months), log-rank test, p = .03. Patients diagnosed with pulmonary arterial hypertension present diminished sTWEAK and P-selectin storage capacity in platelets. Thrombocytes appear to be a major source of sTWEAK that could be released upon local injury and its decreased availability could have an impact on pathophysiology and prognosis in PAH.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 25%
Researcher 3 25%
Professor 2 17%
Student > Ph. D. Student 2 17%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Agricultural and Biological Sciences 2 17%
Immunology and Microbiology 1 8%
Social Sciences 1 8%
Engineering 1 8%
Other 0 0%
Unknown 3 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Cytokine
#2,180
of 2,713 outputs
Outputs of similar age
#384,414
of 444,857 outputs
Outputs of similar age from Cytokine
#22
of 34 outputs
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