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Rarity of the Alzheimer Disease–Protective APP A673T Variant in the United States

Overview of attention for article published in JAMA Neurology, February 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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1 blog
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14 X users
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2 Facebook pages

Citations

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41 Dimensions

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148 Mendeley
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Title
Rarity of the Alzheimer Disease–Protective APP A673T Variant in the United States
Published in
JAMA Neurology, February 2015
DOI 10.1001/jamaneurol.2014.2157
Pubmed ID
Authors

Li-San Wang, Adam C. Naj, Robert R. Graham, Paul K. Crane, Brian W. Kunkle, Carlos Cruchaga, Josue D. Gonzalez Murcia, Lisa Cannon-Albright, Clinton T. Baldwin, Henrik Zetterberg, Kaj Blennow, Walter A. Kukull, Kelley M. Faber, Nicole Schupf, Maria C. Norton, JoAnn T. Tschanz, Ronald G. Munger, Christopher D. Corcoran, Ekaterina Rogaeva, Chiao-Feng Lin, Beth A. Dombroski, Laura B. Cantwell, Amanda Partch, Otto Valladares, Hakon Hakonarson, Peter St George-Hyslop, Robert C. Green, Alison M. Goate, Tatiana M. Foroud, Regina M. Carney, Eric B. Larson, Timothy W. Behrens, John S. K. Kauwe, Jonathan L. Haines, Lindsay A. Farrer, Margaret A. Pericak-Vance, Richard Mayeux, Gerard D. Schellenberg, Marilyn S. Albert, Roger L. Albin, Liana G. Apostolova, Steven E. Arnold, Robert Barber, M. Michael Barmada, Lisa L. Barnes, Thomas G. Beach, James T. Becker, Gary W. Beecham, Duane Beekly, David A. Bennett, Eileen H. Bigio, Thomas D. Bird, Deborah Blacker, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Joseph D. Buxbaum, Nigel J. Cairns, Chuanhai Cao, Chris S. Carlson, Steven L. Carroll, Helena C. Chui, David G. Clark, David H. Cribbs, Elizabeth A. Crocco, Charles DeCarli, Steven T. DeKosky, F. Yesim Demirci, Malcolm Dick, Dennis W. Dickson, Ranjan Duara, Nilufer Ertekin-Taner, Kenneth B. Fallon, Martin R. Farlow, Steven Ferris, Matthew P. Frosch, Douglas R. Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Jonathan D. Glass, Neill R. Graff-Radford, John H. Growdon, Ronald L. Hamilton, Kara L. Hamilton-Nelson, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Gregory A. Jicha, Lee-Way Jin, Gyungah Jun, M. Ilyas Kamboh, Anna Karydas, Jeffrey A. Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, Joel H. Kramer, Patricia Kramer, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, Ge Li, Andrew P. Lieberman, Oscar L. Lopez, Kathryn L. Lunetta, Constantine G. Lyketsos, Wendy J. Mack, Daniel C. Marson, Eden R. Martin, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Ann C. McKee, M. Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Thomas J. Montine, John C. Morris, Jill R. Murrell, John M. Olichney, Joseph E. Parisi, William Perry, Elaine Peskind, Ronald C. Petersen, Aimee Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray Raskind, Eric M. Reiman, Barry Reisberg, Christiane Reitz, John M. Ringman, Erik D. Roberson, Howard J. Rosen, Roger N. Rosenberg, Mary Sano, Andrew J. Saykin, Julie A. Schneider, Lon S. Schneider, William W. Seeley, Amanda G. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, Tricia A. Thornton-Wells, John Q. Trojanowski, Juan C. Troncoso, Debby W. Tsuang, Vivianna M. Van Deerlin, Linda J. Van Eldik, Badri N. Vardarajan, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Jennifer Williamson, Sarah Wishnek, Randall L. Woltjer, Clinton B. Wright, Steven G. Younkin, Chang-En Yu, Lei Yu

Abstract

Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Canada 1 <1%
Unknown 145 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 22%
Professor 17 11%
Other 16 11%
Student > Ph. D. Student 12 8%
Professor > Associate Professor 11 7%
Other 29 20%
Unknown 30 20%
Readers by discipline Count As %
Neuroscience 31 21%
Medicine and Dentistry 23 16%
Biochemistry, Genetics and Molecular Biology 16 11%
Agricultural and Biological Sciences 14 9%
Psychology 5 3%
Other 24 16%
Unknown 35 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2017.
All research outputs
#2,260,902
of 25,374,917 outputs
Outputs from JAMA Neurology
#2,034
of 5,841 outputs
Outputs of similar age
#31,058
of 361,178 outputs
Outputs of similar age from JAMA Neurology
#28
of 80 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,841 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.