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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Acute Inflammatory Responses to Exercise in Patients with Abdominal Aortic Aneurysm
|
|---|---|
| Published in |
Medicine and Science in Sports & Exercise, April 2018
|
| DOI | 10.1249/mss.0000000000001501 |
| Pubmed ID | |
| Authors |
Mark Thomas Windsor, Tom George Bailey, Maria Perissiou, Kim Greaves, Pankaj Jha, Anthony Scott Leicht, Fraser David Russell, Jonathan Golledge, Christopher David Askew |
| Abstract |
Inflammation and extracellular matrix degeneration contribute to abdominal aortic aneurysm (AAA) development. We aimed to assess the effect of exercise intensity on circulating biomarkers of inflammation and extracellular matrix degeneration in patients with AAA and healthy older adults. Twenty patients with AAA (74±6y) and twenty healthy males (72±5y) completed moderate-intensity cycling at 40% peak power output (PPO), higher-intensity intervals at 70% PPO, and control (rest) on separate days. Circulating matrix metalloproteinase-9 (MMP-9), transforming growth factor beta 1 (TGF-β1), interleukin-6 (IL-6), IL-10 and tumour necrosis factor alpha (TNF-α) were analysed at rest, and 0 to 90 min post. Biomarkers at baseline were similar between groups. IL-6 responses to exercise were similar between groups, with a greater increase in ΔIL-6 after moderate-intensity compared to higher-intensity exercise (P<0.001). Delta MMP-9 showed a 118 ng/ml (95% CI, 23 to 214, P=0.02) greater increase immediately after higher-intensity exercise compared to changes in control in both groups. Delta MMP-9 then decreased by 114 ng/ml (18 to 211, P=0.02) 90 min after higher-intensity exercise compared to the changes in control. Delta TNF-α was not different between protocols in healthy adults. In patients with AAA, delta TNF-α showed a greater decrease after higher-intensity compared to moderate-intensity exercise (-6.1 pg/ml, -8.5 to -3.6, P<0.001) and control (-4.9 pg/ml, -7.4 to -2.4, P<0.001). IL-10 and TGF-β1 did not change in either group. These findings suggest that a bout of higher-intensity exercise elicits a greater anti-inflammatory response compared to moderate-intensity exercise, which may be further augmented in patients with AAA. Exercise-induced reductions in biomarkers associated with AAA progression may represent a protective effect of exercise in patients with AAA. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 10 | 40% |
| United Kingdom | 7 | 28% |
| Canada | 2 | 8% |
| Unknown | 6 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 16 | 64% |
| Members of the public | 7 | 28% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 11% |
| Student > Ph. D. Student | 8 | 10% |
| Researcher | 7 | 9% |
| Student > Postgraduate | 6 | 8% |
| Student > Master | 6 | 8% |
| Other | 14 | 18% |
| Unknown | 30 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 15 | 19% |
| Medicine and Dentistry | 10 | 13% |
| Nursing and Health Professions | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Business, Management and Accounting | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 35 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2018.
All research outputs
#2,185,997
of 25,382,440 outputs
Outputs from Medicine and Science in Sports & Exercise
#1,830
of 7,053 outputs
Outputs of similar age
#45,906
of 343,807 outputs
Outputs of similar age from Medicine and Science in Sports & Exercise
#36
of 169 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.1. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,807 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.