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On models of the genetic code generated by binary dichotomic algorithms

Overview of attention for article published in Biosystems, December 2014
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Title
On models of the genetic code generated by binary dichotomic algorithms
Published in
Biosystems, December 2014
DOI 10.1016/j.biosystems.2014.12.001
Pubmed ID
Authors

Markus Gumbel, Elena Fimmel, Alberto Danielli, Lutz Strüngmann

Abstract

In this paper we introduce the concept of a BDA-generated model of the genetic code which is based on binary dichotomic algorithms (BDAs). A BDA-generated model is based on binary dichotomic algorithms (BDAs). Such a BDA partitions the set of 64 codons into two disjoint classes of size 32 each and provides a generalization of known partitions like the Rumer dichotomy. We investigate what partitions can be generated when a set of different BDAs is applied sequentially to the set of codons. The search revealed that these models are able to generate code tables with very different numbers of classes ranging from 2 to 64. We have analyzed whether there are models that map the codons to their amino acids. A perfect matching is not possible. However, we present models that describe the standard genetic code with only few errors. There are also models that map all 64 codons uniquely to 64 classes showing that BDAs can be used to identify codons precisely. This could serve as a basis for further mathematical analysis using coding theory, for example. The hypothesis that BDAs might reflect a molecular mechanism taking place in the decoding center of the ribosome is discussed. The scan demonstrated that binary dichotomic partitions are able to model different aspects of the genetic code very well. The search was performed with our tool Beady-A. This software is freely available at http://mi.informatik.hs-mannheim.de/beady-a. It requires a JVM version 6 or higher.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 10%
United States 1 10%
Netherlands 1 10%
Unknown 7 70%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 30%
Student > Doctoral Student 1 10%
Student > Ph. D. Student 1 10%
Student > Bachelor 1 10%
Student > Master 1 10%
Other 1 10%
Unknown 2 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Biochemistry, Genetics and Molecular Biology 2 20%
Veterinary Science and Veterinary Medicine 1 10%
Computer Science 1 10%
Physics and Astronomy 1 10%
Other 0 0%
Unknown 2 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Biosystems
#884
of 1,012 outputs
Outputs of similar age
#307,685
of 360,168 outputs
Outputs of similar age from Biosystems
#8
of 11 outputs
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