| Title |
Cadherins in tissue architecture and disease
|
|---|---|
| Published in |
Journal of Molecular Medicine, December 2014
|
| DOI | 10.1007/s00109-014-1231-5 |
| Pubmed ID | |
| Authors |
Dietmar Vestweber |
| Abstract |
Cadherins are homophilic cell adhesion molecules that determine tissue architecture and control cell contact formation and dissociation in development and tissue homeostasis of all metazoans. These adhesion molecules mediate homophilic interactions between cells and are linked inside the cell via a complex set of cytosolic factors to the actin cytoskeleton. These interactions are key to the plasticity of intercellular junctions and to the various signaling functions of the cadherins. This forms the basis for cadherin-driven cell behavior, cell differentiation, and regeneration of tissue structures. Consequently, mutations in cadherins are the cause of various human pathologies, with cancer representing one of the most prominent examples. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 55 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 39% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 7 | 12% |
| Student > Doctoral Student | 5 | 9% |
| Professor | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 37% |
| Biochemistry, Genetics and Molecular Biology | 13 | 23% |
| Medicine and Dentistry | 4 | 7% |
| Engineering | 3 | 5% |
| Immunology and Microbiology | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2014.
All research outputs
#20,247,117
of 22,775,504 outputs
Outputs from Journal of Molecular Medicine
#1,340
of 1,550 outputs
Outputs of similar age
#302,551
of 361,224 outputs
Outputs of similar age from Journal of Molecular Medicine
#17
of 29 outputs
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So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.