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Attention Score in Context
| Title |
Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc
|
|---|---|
| Published in |
Signal Transduction and Targeted Therapy, September 2017
|
| DOI | 10.1038/sigtrans.2017.49 |
| Pubmed ID | |
| Authors |
Estelle C Collin, Oliver Carroll, Michelle Kilcoyne, Marianna Peroglio, Eugene See, Doris Hendig, Mauro Alini, Sibylle Grad, Abhay Pandit |
| Abstract |
The depletion of chondroitin sulfates (CSs) within the intervertebral disc (IVD) during degenerative disc disease (DDD) results in a decrease in tissue hydration, a loss of fluid movement, cell apoptosis, a loss of nerve growth inhibition and ultimately, the loss of disc function. To date, little is known with regards to the structure and content of chondroitin sulfates (CSs) during IVD ageing. The behavior of glycosaminoglycans (GAGs), specifically CSs, as well as xylosyltransferase I (XT-I) and glucuronyltransferase I (GT-I), two key enzymes involved in CS synthesis as a primer of glycosaminoglycan (GAG) chain elongation and GAG synthesis in the nucleus pulposus (NP), respectively, were evaluated in a bovine ageing IVD model. Here, we showed significant changes in the composition of GAGs during the disc ageing process (6-month-old, 2-year-old and 8-year-old IVDs representing the immature to mature skeleton). The CS quantity and composition of annulus fibrosus (AF) and NP were determined. The expression of both XT-I and GT-I was detected using immunohistochemistry. A significant decrease in GAGs was observed during the ageing process. CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity, which correlated with a decrease in the expression of both XT-I and GT-I. A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years. These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 23% |
| Student > Bachelor | 6 | 11% |
| Researcher | 5 | 9% |
| Student > Master | 3 | 5% |
| Other | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 20 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Medicine and Dentistry | 7 | 13% |
| Engineering | 4 | 7% |
| Agricultural and Biological Sciences | 3 | 5% |
| Immunology and Microbiology | 2 | 4% |
| Other | 11 | 20% |
| Unknown | 22 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Signal Transduction and Targeted Therapy
#1,419
of 1,523 outputs
Outputs of similar age
#287,126
of 326,430 outputs
Outputs of similar age from Signal Transduction and Targeted Therapy
#9
of 9 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,523 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,430 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.