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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise
|
|---|---|
| Published in |
Journal of Applied Physiology, December 2014
|
| DOI | 10.1152/japplphysiol.00878.2014 |
| Pubmed ID | |
| Authors |
Joshua Denham, Brendan J O'Brien, Francine Z Marques, Fadi J Charchar |
| Abstract |
Physical exercise has proven cardiovascular benefits yet there is no clear understanding of the related molecular mechanisms leading to this. Here we determined the beneficial epigenetic effects of exercise after sprint interval training, a form of exercise known to improve cardio-metabolic health. We quantified genome-wide leukocyte DNA methylation of 12 healthy young (18-24 y) men before and after four weeks (thrice weekly) of sprint interval training using the 450K BeadChip (Illumina) and validated gene expression changes in an extra seven subjects. Exercise increased subjects' cardio-respiratory fitness, maximal running performance and decreased LDL-cholesterol concentration in conjunction with genome-wide DNA methylation changes. Notably, many CpG island and gene promoter regions were demethylated after exercise, indicating increased genome-wide transcriptional changes. Amongst genes with DNA methylation changes, epidermal growth factor (EGF), a ligand of the epidermal growth factor receptor known to be involved in cardiovascular disease, was demethylated and showed decreased mRNA expression. Additionally, we found that microRNA-21 and microRNA-210 gene DNA methylation were altered by exercise causing a cascade effect on the expression of the mature microRNA involved in cardiovascular function. Our findings demonstrate that exercise alters DNA methylation in circulating blood cells in genes and microRNAs associated with cardiovascular physiology. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 24% |
| Canada | 4 | 11% |
| Australia | 3 | 8% |
| South Africa | 3 | 8% |
| United States | 3 | 8% |
| Spain | 2 | 5% |
| Ireland | 2 | 5% |
| Argentina | 1 | 3% |
| Costa Rica | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 42% |
| Scientists | 15 | 39% |
| Practitioners (doctors, other healthcare professionals) | 6 | 16% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 114 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 17% |
| Student > Master | 18 | 16% |
| Student > Bachelor | 11 | 10% |
| Researcher | 9 | 8% |
| Other | 8 | 7% |
| Other | 21 | 18% |
| Unknown | 28 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 16% |
| Sports and Recreations | 16 | 14% |
| Medicine and Dentistry | 15 | 13% |
| Agricultural and Biological Sciences | 14 | 12% |
| Nursing and Health Professions | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 32 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2016.
All research outputs
#1,535,265
of 25,374,647 outputs
Outputs from Journal of Applied Physiology
#854
of 9,077 outputs
Outputs of similar age
#20,250
of 359,920 outputs
Outputs of similar age from Journal of Applied Physiology
#13
of 76 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,077 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.