Title |
Maternal high-fat diet and obesity compromise fetal hematopoiesis
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Published in |
Molecular Metabolism, November 2014
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DOI | 10.1016/j.molmet.2014.11.001 |
Pubmed ID | |
Authors |
Ashley N. Kamimae-Lanning, Stephanie M. Krasnow, Natalya A. Goloviznina, Xinxia Zhu, Quinn R. Roth-Carter, Peter R. Levasseur, Sophia Jeng, Shannon K. McWeeney, Peter Kurre, Daniel L. Marks |
Abstract |
Recent evidence indicates that the adult hematopoietic system is susceptible to diet-induced lineage skewing. It is not known whether the developing hematopoietic system is subject to metabolic programming via in utero high-fat diet (HFD) exposure, an established mechanism of adult disease in several organ systems. We previously reported substantial losses in offspring liver size with prenatal HFD. As the liver is the main hematopoietic organ in the fetus, we asked whether the developmental expansion of the hematopoietic stem and progenitor cell (HSPC) pool is compromised by prenatal HFD and/or maternal obesity. |
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United States | 1 | 11% |
Sweden | 1 | 11% |
Canada | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Science communicators (journalists, bloggers, editors) | 2 | 22% |
Scientists | 1 | 11% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | 1% |
Germany | 1 | 1% |
Unknown | 90 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 11% |
Student > Doctoral Student | 9 | 10% |
Other | 7 | 8% |
Researcher | 6 | 7% |
Other | 24 | 26% |
Unknown | 20 | 22% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 13 | 14% |
Immunology and Microbiology | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 9 | 10% |
Nursing and Health Professions | 5 | 5% |
Other | 16 | 17% |
Unknown | 22 | 24% |