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Metyrosine in Psychosis Associated with 22q11.2 Deletion Syndrome: Case Report

Overview of attention for article published in Journal of Child & Adolescent Psychopharmacology, February 2007
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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4 patents
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1 Google+ user

Citations

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11 Dimensions

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58 Mendeley
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Title
Metyrosine in Psychosis Associated with 22q11.2 Deletion Syndrome: Case Report
Published in
Journal of Child & Adolescent Psychopharmacology, February 2007
DOI 10.1089/cap.2006.0013
Pubmed ID
Authors

Carlo G. Carandang, Monique C. Scholten

Abstract

This report describes the use of metyrosine (Demser) in an adolescent male with psychosis associated with the 22q11.2 deletion syndrome (velocardiofacial syndrome; VCFS), diagnosed by fluorescence in situ hybridization (FISH). He presented with multiple features of 22q11.2 deletion syndrome, including ventricular septal defect, palatal abnormalities, speech and motor delays, attention deficits, mood lability, and psychosis. After a failed trial of an atypical antipsychotic to address the psychosis, metyrosine was initiated, with significant reduction of psychotic symptoms and mood lability. Metyrosine treatment allowed this youth to live at home and to attend school, after months of recurrent psychiatric hospitalizations. The successful treatment of metyrosine for psychosis associated with VCFS represents a first in psychiatry, where a known biochemical abnormality in a psychiatric disorder was corrected by a treatment that targets the biochemical pathway, leading to reduction of psychiatric symptoms and improvement of functioning.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Bachelor 8 14%
Student > Ph. D. Student 7 12%
Researcher 5 9%
Other 5 9%
Other 12 21%
Unknown 10 17%
Readers by discipline Count As %
Medicine and Dentistry 20 34%
Psychology 10 17%
Linguistics 3 5%
Nursing and Health Professions 3 5%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 6 10%
Unknown 13 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2022.
All research outputs
#7,356,550
of 25,377,790 outputs
Outputs from Journal of Child & Adolescent Psychopharmacology
#417
of 1,072 outputs
Outputs of similar age
#38,472
of 168,733 outputs
Outputs of similar age from Journal of Child & Adolescent Psychopharmacology
#1
of 7 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,072 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,733 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them