| Title |
Evaluating cognition in individuals with Huntington disease: Neuro-QoL cognitive functioning measures
|
|---|---|
| Published in |
Quality of Life Research, December 2017
|
| DOI | 10.1007/s11136-017-1755-6 |
| Pubmed ID | |
| Authors |
Jin-Shei Lai, Siera Goodnight, Nancy R. Downing, Rebecca E. Ready, Jane S. Paulsen, Anna L. Kratz, Julie C. Stout, Michael K. McCormack, David Cella, Christopher Ross, Jenna Russell, Noelle E. Carlozzi |
| Abstract |
Cognitive functioning impacts health-related quality of life (HRQOL) for individuals with Huntington disease (HD). The Neuro-QoL includes two patient-reported outcome (PRO) measures of cognition-Executive Function (EF) and General Concerns (GC). These measures have not previously been validated for use in HD. The purpose of this analysis is to evaluate the reliability and validity of the Neuro-QoL Cognitive Function measures for use in HD. Five hundred ten individuals with prodromal or manifest HD completed the Neuro-QoL Cognition measures, two other PRO measures of HRQOL (WHODAS 2.0 and EQ5D), and a depression measure (PROMIS Depression). Measures of functioning The Total Functional Capacity and behavior (Problem Behaviors Assessment) were completed by clinician interview. Objective measures of cognition were obtained using clinician-administered Symbol Digit Modalities Test and the Stroop Test (Word, Color, and Interference). Self-rated, clinician-rated, and objective composite scores were developed. We examined the Neuro-QoL measures for reliability, convergent validity, discriminant validity, and known-groups validity. Excellent reliabilities (Cronbach's alphas ≥ 0.94) were found. Convergent validity was supported, with strong relationships between self-reported measures of cognition. Discriminant validity was supported by less robust correlations between self-reported cognition and other constructs. Prodromal participants reported fewer cognitive problems than manifest groups, and early-stage HD participants reported fewer problems than late-stage HD participants. The Neuro-QoL Cognition measures provide reliable and valid assessments of self-reported cognitive functioning for individuals with HD. Findings support the utility of these measures for assessing self-reported cognition. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 9 | 9% |
| Student > Bachelor | 9 | 9% |
| Other | 6 | 6% |
| Researcher | 6 | 6% |
| Other | 16 | 17% |
| Unknown | 35 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 19 | 20% |
| Medicine and Dentistry | 12 | 13% |
| Nursing and Health Professions | 8 | 8% |
| Neuroscience | 6 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 36 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2017.
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#18,578,649
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Outputs from Quality of Life Research
#2,071
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#327,466
of 439,767 outputs
Outputs of similar age from Quality of Life Research
#46
of 66 outputs
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