Title |
Assessment of TANK‐binding kinase 1 as a therapeutic target in cancer
|
---|---|
Published in |
Journal of Cell Communication and Signaling, December 2017
|
DOI | 10.1007/s12079-017-0438-y |
Pubmed ID | |
Authors |
Victoria H. Cruz, Rolf A. Brekken |
Abstract |
TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 19% |
Student > Bachelor | 6 | 13% |
Student > Doctoral Student | 6 | 13% |
Researcher | 6 | 13% |
Student > Ph. D. Student | 3 | 6% |
Other | 5 | 11% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 36% |
Agricultural and Biological Sciences | 5 | 11% |
Immunology and Microbiology | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Business, Management and Accounting | 1 | 2% |
Other | 5 | 11% |
Unknown | 15 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2021.
All research outputs
#7,030,867
of 23,011,300 outputs
Outputs from Journal of Cell Communication and Signaling
#50
of 270 outputs
Outputs of similar age
#139,968
of 440,043 outputs
Outputs of similar age from Journal of Cell Communication and Signaling
#3
of 18 outputs
Altmetric has tracked 23,011,300 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 270 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,043 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.