Title |
Environmental Perchlorate and Thiocyanate Exposures and Infant Serum Thyroid Function
|
---|---|
Published in |
Thyroid, July 2012
|
DOI | 10.1089/thy.2012.0058 |
Pubmed ID | |
Authors |
Angela M. Leung, Lewis E. Braverman, Xuemei He, Kristin E. Schuller, Alexandra Roussilhes, Katherine A. Jahreis, Elizabeth N. Pearce |
Abstract |
Breastfed infants rely on maternal iodine for thyroid hormone production required for neurodevelopment. Dietary iodine among women of childbearing age in the United States may be insufficient. Perchlorate (competitive inhibitor of the sodium/iodide symporter [NIS]) exposure is ubiquitous. Thiocyanate, from cigarettes and diet, is a weaker NIS inhibitor. Environmental perchlorate and thiocyanate exposures could decrease breast milk iodine by competitively inhibiting NIS in lactating breasts (thus impairing infants' iodine availability), and/or infants' thyroidal NIS to directly decrease infant thyroid function. The current study assessed the relationships between environmental perchlorate and thiocyanate exposures and infant serum thyroid function. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 15% |
Researcher | 8 | 13% |
Student > Master | 8 | 13% |
Student > Bachelor | 7 | 11% |
Other | 3 | 5% |
Other | 8 | 13% |
Unknown | 18 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 21% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
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Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 12 | 20% |
Unknown | 19 | 31% |