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Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain

Overview of attention for article published in Frontiers in Neuroanatomy, December 2014
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Title
Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain
Published in
Frontiers in Neuroanatomy, December 2014
DOI 10.3389/fnana.2014.00148
Pubmed ID
Authors

Thomas Klarić, Michael Lardelli, Brian Key, Simon Koblar, Martin Lewis

Abstract

In rodents, the Npas4 gene has recently been identified as being an important regulator of synaptic plasticity and memory. Homologs of Npas4 have been found in invertebrate species though their functions appear to be too divergent for them to be studied as a proxy for the mammalian proteins. The aim of this study, therefore, was to ascertain the suitability of the zebrafish as a model organism for investigating the function of Npas4 genes. We show here that the expression and regulation of the zebrafish Npas4 homolog, npas4a, is remarkably similar to that of the rodent Npas4 genes. As in mammals, expression of the zebrafish npas4a gene is restricted to the brain where it is up-regulated in response to neuronal activity. Furthermore, we also show that knockdown of npas4a during embryonic development results in a number of forebrain-specific defects including increased apoptosis and misexpression of the forebrain marker genes dlx1a and shha. Our work demonstrates that the zebrafish is a suitable model organism for investigating the role of the npas4a gene and one that is likely to provide valuable insights into the function of the mammalian homologs. Furthermore, our findings highlight a potential role for npas4a in forebrain development.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Croatia 1 3%
India 1 3%
United States 1 3%
Portugal 1 3%
Unknown 35 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Student > Master 7 18%
Researcher 4 10%
Student > Bachelor 4 10%
Student > Doctoral Student 3 8%
Other 3 8%
Unknown 9 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Biochemistry, Genetics and Molecular Biology 7 18%
Neuroscience 6 15%
Medicine and Dentistry 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%
Unknown 11 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2014.
All research outputs
#15,313,289
of 22,775,504 outputs
Outputs from Frontiers in Neuroanatomy
#788
of 1,159 outputs
Outputs of similar age
#213,598
of 360,787 outputs
Outputs of similar age from Frontiers in Neuroanatomy
#25
of 40 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,159 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,787 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.