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Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue

Overview of attention for article published in Applied Physiology, Nutrition, and Metabolism, August 2017
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Title
Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue
Published in
Applied Physiology, Nutrition, and Metabolism, August 2017
DOI 10.1139/apnm-2016-0725
Pubmed ID
Authors

Maja Bundalo, Ana Djordjevic, Biljana Bursac, Maja Zivkovic, Goran Koricanac, Aleksandra Stanković

Abstract

The adipose tissue renin-angiotensin system (RAS) is proposed to be a pathophysiological link between adipose tissue dysregulation and metabolic disorders induced by fructose rich diet (FRD). RAS can act intracellularly. We hypothesized that adipocytes nuclear membranes possess angiotensin receptors type 1 and type 2 (AT1R and AT2R) that couple to nuclear signaling pathways and regulate oxidative gene expression under the FRD. We analyzed the effect of nine-week consumption of 10% fructose solution on biochemical parameters, adipocyte morphology and expression of AT1R, AT2R, AT1R-associated protein (ATRAP), NOX4, MMP-9, and MnSOD in adipose tissue of Wistar rats. We detected AT1R and AT2R in nuclear fraction. FRD decreased protein level of nuclear angiotensin receptors, while increased AT1R and decreased AT2R levels were observed at plasma membrane. FRD increased mRNA level of ATRAP, while MnSOD mRNA and protein levels were decreased. No significant differences were observed for MMP9 and NOX4 mRNA levels. These findings coincide with hyperleptinemia, elevated blood pressure and triglyceride level, as well as with unchanged visceral adipose tissue mass and morphology upon FRD. Besides providing evidence for nuclear localization of angiotensin receptors in visceral adipose tissue, this study also points to the different effect of FRD on AT1R expression in different cellular compartments. Elevated blood pressure and decreased antioxidative capacity in visceral fat of fructose fed rats were accompanied by an increased AT1R level in plasma membrane while upregulation of ATRAP and decrease of nuclear membrane AT1R suggest an increase in capacity for attenuation of excessive AT1R signaling and visceral adiposity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Student > Ph. D. Student 2 14%
Professor 1 7%
Librarian 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 5 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 29%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Agricultural and Biological Sciences 1 7%
Computer Science 1 7%
Social Sciences 1 7%
Other 0 0%
Unknown 6 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2017.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from Applied Physiology, Nutrition, and Metabolism
#1,895
of 2,327 outputs
Outputs of similar age
#253,170
of 327,246 outputs
Outputs of similar age from Applied Physiology, Nutrition, and Metabolism
#43
of 50 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,327 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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