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X Demographics
Mendeley readers
Attention Score in Context
| Title |
β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case–control study
|
|---|---|
| Published in |
International Journal of Antimicrobial Agents, December 2014
|
| DOI | 10.1016/j.ijantimicag.2014.11.005 |
| Pubmed ID | |
| Authors |
Katia Donadello, Elio Antonucci, Stefano Cristallini, Jason A. Roberts, Marjorie Beumier, Sabino Scolletta, Frédérique Jacobs, Benoit Rondelet, Daniel de Backer, Jean-Louis Vincent, Fabio Silvio Taccone |
| Abstract |
Most adult patients receiving extracorporeal membrane oxygenation (ECMO) require antibiotic therapy, however the pharmacokinetics of β-lactams have not been well studied in these conditions. In this study, data from all patients receiving ECMO support and meropenem (MEM) or piperacillin/tazobactam (TZP) were reviewed. Drug concentrations were measured 2h after the start of a 30-min infusion and just before the subsequent dose. Therapeutic drug monitoring (TDM) results in ECMO patients were matched with those in non-ECMO patients for (i) drug regimen, (ii) renal function, (iii) total body weight, (iv) severity of organ dysfunction and (v) age. Drug concentrations were considered adequate if they remained 4-8× the clinical MIC breakpoint for Pseudomonas aeruginosa for 50% (TZP) or 40% (MEM) of the dosing interval. A total of 41 TDM results (27 MEM; 14 TZP) were obtained in 26 ECMO patients, with 41 matched controls. There were no significant differences in serum concentrations or pharmacokinetic parameters between ECMO and non-ECMO patients, including Vd [0.38 (0.27-0.68) vs. 0.46 (0.33-0.79)L/kg; P=0.37], half-life [2.6 (1.8-4.4) vs. 2.9 (1.7-3.7)h; P=0.96] and clearance [132 (66-200) vs. 141 (93-197)mL/min; P=0.52]. The proportion of insufficient (13/41 vs. 12/41), adequate (15/41 vs. 19/41) and excessive (13/41 vs. 10/41) drug concentrations was similar in ECMO and non-ECMO patients. Achievement of target concentrations of these β-lactams was poor in ECMO and non-ECMO patients. The influence of ECMO on MEM and TZP pharmacokinetics does not appear to be significant. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 32% |
| Belgium | 2 | 11% |
| Malaysia | 1 | 5% |
| India | 1 | 5% |
| Colombia | 1 | 5% |
| Spain | 1 | 5% |
| United States | 1 | 5% |
| Unknown | 6 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 58% |
| Scientists | 6 | 32% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| Germany | 1 | 1% |
| France | 1 | 1% |
| Unknown | 86 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 15% |
| Other | 11 | 12% |
| Student > Doctoral Student | 10 | 11% |
| Student > Postgraduate | 8 | 9% |
| Researcher | 6 | 7% |
| Other | 12 | 13% |
| Unknown | 29 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 33% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 17% |
| Chemistry | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Agricultural and Biological Sciences | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 36 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#4,191,555
of 25,373,627 outputs
Outputs from International Journal of Antimicrobial Agents
#551
of 3,028 outputs
Outputs of similar age
#55,351
of 368,077 outputs
Outputs of similar age from International Journal of Antimicrobial Agents
#6
of 52 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,028 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,077 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.