| Title |
Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases
|
|---|---|
| Published in |
Basic Research in Cardiology, December 2017
|
| DOI | 10.1007/s00395-017-0663-9 |
| Pubmed ID | |
| Authors |
Dongling Liu, Xiang Zeng, Xiao Li, Jawahar L. Mehta, Xianwei Wang |
| Abstract |
NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls inflammatory responses and coordinates antimicrobial host defenses by activating caspase-1 for the subsequent maturation of pro-inflammatory cytokines, IL-1β and IL-18, and induces pyroptosis. The assembly and activation of NLRP3 inflammasome are linked to the pathogenesis of several cardiovascular disease risk factors, such as hypertension and diabetes, and their major consequences-myocardial remodeling. The study of the NLRP3 inflammasome in these cardiovascular disease states may uncover important triggers and endogenous modulators of the disease, and lead to new treatment strategies. This review outlines current insights into NLRP3 inflammasome research associated with cardiovascular diseases and discusses the questions that remain in this field. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 12% |
| Student > Ph. D. Student | 13 | 11% |
| Researcher | 12 | 10% |
| Student > Bachelor | 11 | 9% |
| Student > Postgraduate | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 44 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 24% |
| Biochemistry, Genetics and Molecular Biology | 15 | 12% |
| Immunology and Microbiology | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Agricultural and Biological Sciences | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 50 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2023.
All research outputs
#6,992,179
of 25,998,826 outputs
Outputs from Basic Research in Cardiology
#177
of 754 outputs
Outputs of similar age
#125,680
of 451,297 outputs
Outputs of similar age from Basic Research in Cardiology
#1
of 5 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 754 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them