Title |
Metabolic effects of resveratrol: addressing the controversies
|
---|---|
Published in |
Cellular and Molecular Life Sciences, December 2014
|
DOI | 10.1007/s00018-014-1808-8 |
Pubmed ID | |
Authors |
Jacob L. Bitterman, Jay H. Chung |
Abstract |
Resveratrol, a polyphenol found in a number of plant-based foods such as red wine, has received a great deal of attention for its diverse array of healthful effects. Beneficial effects of resveratrol are diverse; they include improvement of mitochondrial function, protection against obesity and obesity-related diseases such as type-2 diabetes, suppression of inflammation and cancer cell growth and protection against cardiovascular dysfunction, just to name a few. Investigations into the metabolic effects of resveratrol are furthest along and now include a number of clinical trials, which have yielded mixed results. There are a number of controversies surrounding resveratrol that have not been resolved. Here, we will review these controversies with particular emphasis on its mechanism of metabolic action and how lessons from resveratrol may help develop therapies that harness the effects of resveratrol but without the undesirable properties of resveratrol. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Italy | 2 | 40% |
United States | 1 | 20% |
India | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 1% |
France | 2 | 1% |
Finland | 1 | <1% |
Unknown | 138 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 27 | 19% |
Student > Master | 22 | 15% |
Student > Bachelor | 16 | 11% |
Researcher | 14 | 10% |
Other | 6 | 4% |
Other | 26 | 18% |
Unknown | 32 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 29% |
Agricultural and Biological Sciences | 21 | 15% |
Biochemistry, Genetics and Molecular Biology | 18 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Chemistry | 6 | 4% |
Other | 14 | 10% |
Unknown | 37 | 26% |