| Title |
Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond
|
|---|---|
| Published in |
Diabetologia, September 2017
|
| DOI | 10.1007/s00125-017-4435-8 |
| Pubmed ID | |
| Authors |
Hans-Peter Hammes |
| Abstract |
Diabetic retinopathy remains a relevant clinical problem. In parallel with diagnostic and therapeutic improvements, the role of glycaemia and reactive metabolites causing cell stress and biochemical abnormalities as treatment targets needs continuous re-evaluation. Furthermore, the basic mechanisms of physiological angiogenesis, remodelling and pruning give important clues about the origins of vasoregression during the very early stages of diabetic retinopathy and can be modelled in animals. This review summarises evidence supporting a role for the neurovascular unit-composed of neuronal, glial and vascular cells-as a responder to the biochemical changes imposed by reactive metabolites and high glucose. Normoglycaemic animal models developing retinal degeneration, provide valuable information about common pathways downstream of progressive neuronal damage that induce vasoregression, as in diabetic models. These models can serve to assess novel treatments addressing the entire neurovascular unit for the benefit of early diabetic retinopathy. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 17% |
| Spain | 4 | 9% |
| Denmark | 2 | 4% |
| Germany | 2 | 4% |
| Canada | 2 | 4% |
| United States | 2 | 4% |
| France | 1 | 2% |
| Mexico | 1 | 2% |
| Australia | 1 | 2% |
| Other | 5 | 11% |
| Unknown | 18 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 70% |
| Scientists | 7 | 15% |
| Practitioners (doctors, other healthcare professionals) | 6 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 193 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 31 | 16% |
| Student > Ph. D. Student | 18 | 9% |
| Student > Master | 18 | 9% |
| Student > Doctoral Student | 18 | 9% |
| Other | 16 | 8% |
| Other | 36 | 19% |
| Unknown | 56 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 28% |
| Biochemistry, Genetics and Molecular Biology | 29 | 15% |
| Agricultural and Biological Sciences | 12 | 6% |
| Nursing and Health Professions | 5 | 3% |
| Neuroscience | 5 | 3% |
| Other | 25 | 13% |
| Unknown | 62 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2018.
All research outputs
#1,397,128
of 24,223,370 outputs
Outputs from Diabetologia
#768
of 5,233 outputs
Outputs of similar age
#28,720
of 323,600 outputs
Outputs of similar age from Diabetologia
#23
of 85 outputs
Altmetric has tracked 24,223,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,233 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.