Title |
Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness
|
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Published in |
Clinical Infectious Diseases, December 2014
|
DOI | 10.1093/cid/ciu1152 |
Pubmed ID | |
Authors |
Martin Walker, Sabine Specht, Thomas S. Churcher, Achim Hoerauf, Mark J. Taylor, María-Gloria Basáñez |
Abstract |
Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility and survival. Clinical trials have shown that doxycycline treatment eliminates Wolbachia causing long-term sterilization of adult female filariae, effecting potent macrofilaricidal activity. The continual reinfection by drug-naïve worms that occurs in these trial settings dilutes observable anti-Wolbachia and antifilarial effects, making it difficult to estimate therapeutic efficacy and compare different doxycycline regimens, evaluated at different times post-treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 17% |
Bolivia, Plurinational State of | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Unknown | 81 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 23% |
Student > Ph. D. Student | 15 | 18% |
Student > Master | 10 | 12% |
Other | 7 | 8% |
Student > Bachelor | 7 | 8% |
Other | 13 | 16% |
Unknown | 12 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 23% |
Agricultural and Biological Sciences | 14 | 17% |
Immunology and Microbiology | 10 | 12% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Nursing and Health Professions | 5 | 6% |
Other | 13 | 16% |
Unknown | 15 | 18% |