| Chapter title |
Sleep Deprivation Therapy for Depression
|
|---|---|
| Chapter number | 363 |
| Book title |
Sleep, Neuronal Plasticity and Brain Function
|
| Published in |
Current topics in behavioral neurosciences, December 2014
|
| DOI | 10.1007/7854_2014_363 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-246877-7, 978-3-66-246878-4
|
| Authors |
Sara Dallaspezia, Francesco Benedetti, Dallaspezia S, Benedetti F, Dallaspezia, Sara, Benedetti, Francesco |
| Abstract |
Sleep deprivation (SD) is the most widely documented rapid-onset antidepressant therapy, targeting the broadly defined depressive syndrome. Although SD responses are transient, its effects can be sustained by concomitant medications (e.g., selective serotonin reuptake inhibitors and lithium) and circadian-related interventions (e.g., bright light and sleep phase advance). Thus, considering its safety, this technique can now be considered among the first-line antidepressant treatment strategies for patients affected by mood disorders. SD is a complex intervention and it should be considered multi-target in nature. Thus, the mechanisms explaining its antidepressant effect can be looked for on many levels, involving not only monoaminergic mechanisms but also sleep homeostatic and circadian mechanisms, glutamatergic mechanisms and synaptic plasticity. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 18% |
| United Kingdom | 5 | 10% |
| Spain | 4 | 8% |
| Ecuador | 1 | 2% |
| Singapore | 1 | 2% |
| Germany | 1 | 2% |
| Netherlands | 1 | 2% |
| Australia | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 78% |
| Scientists | 4 | 8% |
| Practitioners (doctors, other healthcare professionals) | 4 | 8% |
| Science communicators (journalists, bloggers, editors) | 3 | 6% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 96 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 20% |
| Student > Bachelor | 17 | 18% |
| Student > Ph. D. Student | 17 | 18% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 8 | 8% |
| Other | 14 | 14% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 26% |
| Neuroscience | 18 | 19% |
| Psychology | 15 | 15% |
| Agricultural and Biological Sciences | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Other | 9 | 9% |
| Unknown | 16 | 16% |