| Title |
Antimicrobial activity of prodigiosin isolated from Serratia marcescens UFPEDA 398
|
|---|---|
| Published in |
World Journal of Microbiology and Biotechnology, December 2014
|
| DOI | 10.1007/s11274-014-1793-y |
| Pubmed ID | |
| Authors |
J. C. Lapenda, P. A. Silva, M. C. Vicalvi, K. X. F. R. Sena, S. C. Nascimento |
| Abstract |
Prodigiosin is an alkaloid and natural red pigment produced by Serratia marcescens. Prodigiosin has antimicrobial, antimalarial and antitumor properties and induces apoptosis in T and B lymphocytes. These properties have piqued the interest of researchers in the fields of medicine, pharmaceutics and different industries. The aim of the present study was to evaluate the antimicrobial activity of prodigiosin against pathogenic micro-organisms. The red pigments produced by S. marcescens exhibited absorption at 534 nm, Rf of 0.59 and molecular weight of 323 m/z. Antimicrobial activity was tested against oxacillin-resistant Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pyogenes, Acinetobacter sp. and oxacillin-resistant S. aureus. The standard antibiotics employed were ampicillin, chloramphenicol, gentamicin and oxacillin. The disc-diffusion tests demonstrated significant inhibition zones for S. aureus (35 ± 0.6), E. faecalis (22 ± 1.0) and S. pyogenes (14 ± 0.6). However, prodigiosin showed resistance to E. coli, P. aeruginosa and acinetobacter, where no significant formation of inhibitory halos were observed. We determined the inhibitory minimum concentrations and bactericidal for 20 strains of oxacillin-resistant S. aureus (ORSA). The pattern was the antibiotic oxacillin. The minimum inhibitory concentrations observed ranged from 1, 2 and 4.0 μg/mL, respectively, while the minimum bactericidal concentrations ranged from 2, 4, 8 and 16 μg/mL. The S. marcescens prodigiosin produced by showed bactericidal and bacteriostatic effect showing promising antimicrobial activity and suggesting future studies regarding its applicability in antibiotics therapies directed ORSA. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| India | 1 | <1% |
| Unknown | 173 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 22% |
| Student > Ph. D. Student | 26 | 15% |
| Researcher | 19 | 11% |
| Student > Master | 13 | 7% |
| Student > Postgraduate | 9 | 5% |
| Other | 23 | 13% |
| Unknown | 48 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 23% |
| Agricultural and Biological Sciences | 32 | 18% |
| Immunology and Microbiology | 17 | 10% |
| Chemistry | 14 | 8% |
| Environmental Science | 6 | 3% |
| Other | 19 | 11% |
| Unknown | 48 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2015.
All research outputs
#16,223,992
of 23,911,072 outputs
Outputs from World Journal of Microbiology and Biotechnology
#990
of 1,757 outputs
Outputs of similar age
#215,497
of 358,763 outputs
Outputs of similar age from World Journal of Microbiology and Biotechnology
#5
of 18 outputs
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So far Altmetric has tracked 1,757 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.