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Vascular Calcification: The Killer of Patients with Chronic Kidney Disease

Overview of attention for article published in Journal of the American Society of Nephrology, May 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
10 X users
patent
3 patents
facebook
1 Facebook page

Citations

dimensions_citation
445 Dimensions

Readers on

mendeley
298 Mendeley
citeulike
1 CiteULike
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Title
Vascular Calcification: The Killer of Patients with Chronic Kidney Disease
Published in
Journal of the American Society of Nephrology, May 2009
DOI 10.1681/asn.2008070692
Pubmed ID
Authors

Masahide Mizobuchi, Dwight Towler, Eduardo Slatopolsky

Abstract

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). Vascular calcification is a common complication in CKD, and investigators have demonstrated that the extent and histoanatomic type of vascular calcification are predictors of subsequent vascular mortality. Although research efforts in the past decade have greatly improved our knowledge of the multiple factors and mechanisms involved in vascular calcification in patients with kidney disease, many questions remain unanswered. No longer can we accept the concept that vascular calcification in CKD is a passive process resulting from an elevated calcium-phosphate product. Rather, as a result of the metabolic insults of diabetes, dyslipidemia, oxidative stress, uremia, and hyperphosphatemia, "osteoblast-like" cells form in the vessel wall. These mineralizing cells as well as the recruitment of undifferentiated progenitors to the osteochondrocyte lineage play a critical role in the calcification process. Important transcription factors such as Msx 2, osterix, and RUNX2 are crucial in the programming of osteogenesis. Thus, the simultaneous increase in arterial osteochondrocytic programs and reduction in active cellular defense mechanisms creates the "perfect storm" of vascular calcification seen in ESRD. Innovative clinical studies addressing the combined use of inhibitors that work on vascular calcification through distinct molecular mechanisms, such as fetuin-A, osteopontin, and bone morphogenic protein 7, among others, will be necessary to reduce significantly the accrual of vascular calcifications and cardiovascular mortality in kidney disease. In addition, the roles of oxidative stress and inflammation on the fate of smooth muscle vascular cells and their function deserve further translational investigation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 298 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 <1%
United States 2 <1%
India 2 <1%
Canada 2 <1%
Chile 1 <1%
Germany 1 <1%
Slovenia 1 <1%
Australia 1 <1%
Russia 1 <1%
Other 3 1%
Unknown 282 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 19%
Researcher 43 14%
Student > Master 40 13%
Student > Bachelor 32 11%
Other 28 9%
Other 55 18%
Unknown 44 15%
Readers by discipline Count As %
Medicine and Dentistry 113 38%
Agricultural and Biological Sciences 49 16%
Biochemistry, Genetics and Molecular Biology 33 11%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Engineering 12 4%
Other 27 9%
Unknown 52 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2021.
All research outputs
#1,270,231
of 25,373,627 outputs
Outputs from Journal of the American Society of Nephrology
#681
of 5,680 outputs
Outputs of similar age
#3,605
of 124,790 outputs
Outputs of similar age from Journal of the American Society of Nephrology
#3
of 56 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,680 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,790 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.