Chapter title |
Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses.
|
---|---|
Chapter number | 1 |
Book title |
IgE Antibodies: Generation and Function
|
Published in |
Current topics in microbiology and immunology, January 2015
|
DOI | 10.1007/978-3-319-13725-4_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-913724-7, 978-3-31-913725-4
|
Authors |
Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J Lafaille, Maria A Curotto de Lafaille, Juan J. Lafaille, Maria A. Curotto de Lafaille, He, Jin-Shu, Narayanan, Sriram, Subramaniam, Sharrada, Ho, Wen Qi, Lafaille, Juan J., Curotto de Lafaille, Maria A. |
Abstract |
The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodiesIgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE is also the main culprit responsible for the manifestations of allergic disease, including life-threatening anaphylaxisAnaphylaxis . Thus, generation of high-affinity IgE must be tightly regulated. Recent studies of IgE B cell biology have unveiled two mechanisms that limit high-affinity IgE memory responses: First, B cells that have recently switched to IgE production are programmed to rapidly differentiate into plasma cells,Plasma cells and second, IgE germinal centerGerminal center cells are transient and highly apoptotic. Opposing these processes, we now know that germinal center-derived IgG B cells can switch to IgE production, effectively becoming IgE-producing plasma cells. In this chapter, we will discuss the unique molecular and cellular pathways involved in the generation of IgE antibodies. |
X Demographics
Geographical breakdown
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Germany | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Netherlands | 1 | 1% |
Unknown | 75 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 17% |
Student > Bachelor | 13 | 17% |
Researcher | 11 | 14% |
Student > Master | 11 | 14% |
Student > Postgraduate | 2 | 3% |
Other | 7 | 9% |
Unknown | 19 | 25% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 17 | 22% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Medicine and Dentistry | 9 | 12% |
Agricultural and Biological Sciences | 8 | 11% |
Nursing and Health Professions | 3 | 4% |
Other | 10 | 13% |
Unknown | 19 | 25% |