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Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2005
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

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2 X users
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5 Wikipedia pages

Citations

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251 Dimensions

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207 Mendeley
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1 CiteULike
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Title
Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism
Published in
Proceedings of the National Academy of Sciences of the United States of America, April 2005
DOI 10.1073/pnas.0501814102
Pubmed ID
Authors

Katarzyna Lundmark, Gunilla T. Westermark, Arne Olsén, Per Westermark

Abstract

Secondary, or amyloid protein A (AA), amyloidosis is a complication of chronic inflammatory diseases, both infectious and noninfectious. AA constitutes the insoluble fibrils, which are deposited in different organs, and is a major N-terminal part of the acute phase protein serum AA. It is not known why only some patients with chronic inflammation develop AA amyloidosis. Nucleation is a widely accepted mechanism in amyloidogenesis. Preformed amyloid-like fibrils act as nuclei in amyloid fibril formation in vitro, and AA amyloid fibrils and synthetic amyloid-like fibrils also may serve as seed for fibril formation in vivo. In addition to amyloid fibrils, there is a variety of similar nonmammalian protein fibrils with beta-pleated structure in nature. We studied three such naturally occurring protein fibrils: silk from Bombyx mori, Sup35 from Saccharomyces cerevisiae, and curli from Escherichia coli. Our results show that these protein fibrils exert amyloid-accelerating properties in the murine experimental AA amyloidosis, suggesting that such environment factors may be important risk factors in amyloidogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
United Kingdom 1 <1%
Chile 1 <1%
South Africa 1 <1%
Unknown 202 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 20%
Researcher 37 18%
Student > Bachelor 26 13%
Student > Master 18 9%
Student > Doctoral Student 13 6%
Other 34 16%
Unknown 37 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 54 26%
Biochemistry, Genetics and Molecular Biology 41 20%
Chemistry 15 7%
Medicine and Dentistry 15 7%
Neuroscience 14 7%
Other 26 13%
Unknown 42 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#7,488,195
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#62,059
of 101,438 outputs
Outputs of similar age
#20,886
of 62,054 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#311
of 519 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,054 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 519 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.