Title |
MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma
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Published in |
BMC Cancer, December 2014
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DOI | 10.1186/1471-2407-14-962 |
Pubmed ID | |
Authors |
Maria Eldh, Roger Olofsson Bagge, Cecilia Lässer, Joar Svanvik, Margareta Sjöstrand, Jan Mattsson, Per Lindnér, Dong-Sic Choi, Yong Song Gho, Jan Lötvall |
Abstract |
Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including malignant melanoma cells. This clinical translational study included patients undergoing isolated hepatic perfusion (IHP) for metastatic uveal melanoma, from whom exosomes were isolated directly from liver perfusates. The objective was to determine whether exosomes are present in the liver circulation, and to ascertain whether these may originate from melanoma cells. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Denmark | 2 | 2% |
Turkey | 1 | <1% |
Unknown | 112 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 24 | 21% |
Researcher | 20 | 17% |
Student > Master | 15 | 13% |
Student > Bachelor | 11 | 10% |
Professor > Associate Professor | 10 | 9% |
Other | 19 | 17% |
Unknown | 16 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 28 | 24% |
Biochemistry, Genetics and Molecular Biology | 27 | 23% |
Agricultural and Biological Sciences | 18 | 16% |
Chemistry | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 11 | 10% |
Unknown | 24 | 21% |