Title |
Cellular Physiology and Clinical Manifestations of Fascicular Arrhythmias in Normal Hearts
|
---|---|
Published in |
JACC: Clinical Electrophysiology, September 2017
|
DOI | 10.1016/j.jacep.2017.07.011 |
Pubmed ID | |
Authors |
Raphael K. Sung, Penelope A. Boyden, Melvin Scheinman |
Abstract |
Fascicular ventricular arrhythmias represent a spectrum of ventricular tachycardias dependent on the specialized conduction system. Although they are more common in structurally abnormal hearts, there is an increasing body of literature describing their role in normal hearts. In this review, the authors present data from both basic and clinical research that explore the current understanding of idiopathic fascicular ventricular arrhythmias. Evaluation of the cellular electrophysiology of the Purkinje cells shows clear evidence of enhanced automaticity and triggered activity as potential mechanisms of arrhythmias. Perhaps more importantly, heterogeneity in conduction system velocity and refractoriness of the left ventricular conduction system in animal models are in line with clinical descriptions of re-entrant fascicular arrhythmias in humans. Further advances in our understanding of the conduction system will help bridge the current gap between basic science and clinical fascicular arrhythmias. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 30% |
Spain | 6 | 12% |
Mexico | 2 | 4% |
Argentina | 2 | 4% |
Colombia | 2 | 4% |
Turkey | 2 | 4% |
Italy | 2 | 4% |
Venezuela, Bolivarian Republic of | 1 | 2% |
China | 1 | 2% |
Other | 3 | 6% |
Unknown | 14 | 28% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 30 | 60% |
Practitioners (doctors, other healthcare professionals) | 13 | 26% |
Science communicators (journalists, bloggers, editors) | 4 | 8% |
Scientists | 3 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 21% |
Student > Ph. D. Student | 6 | 15% |
Student > Postgraduate | 4 | 10% |
Professor > Associate Professor | 4 | 10% |
Student > Master | 4 | 10% |
Other | 9 | 23% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 54% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 8% |
Unknown | 10 | 26% |