| Title |
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease
|
|---|---|
| Published in |
NeuroMolecular Medicine, January 2014
|
| DOI | 10.1007/s12017-014-8288-8 |
| Pubmed ID | |
| Authors |
Mirjam I. Lutz, Ivan Milenkovic, Günther Regelsberger, Gabor G. Kovacs |
| Abstract |
Aging is one of the major risk factors for Alzheimer's disease (AD). Sirtuins are associated with prolonged life span. To examine whether the expression levels of sirtuins associate with the progression of AD or not, we performed a comparative immunoblotting and immunohistochemical study of SIRT1, 3, and 5 in the entorhinal cortex and hippocampal subregions and white matter in 45 cases grouped according to Braak and Braak stages of neurofibrillary degeneration. In addition, we compared the expression levels with the local load of tau and amyloid-beta deposits, evaluated using morphometry. Our study revealed that (1) the neuronal subcellular redistribution of SIRT1 parallels the decrease in its expression, suggesting stepwise loss of neuroprotection dependent on the neuronal population; (2) in contrast to SIRT1 and 3, expression of SIRT5 increases during the progression of AD; (3) which might be related to its appearance in activated microglial cells. The complex patterns of the expression of sirtuins in relation to tissue damage should be taken into account when searching for therapies interacting with sirtuins. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 24% |
| Researcher | 13 | 14% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 6 | 6% |
| Other | 11 | 12% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 25% |
| Biochemistry, Genetics and Molecular Biology | 13 | 14% |
| Neuroscience | 10 | 11% |
| Medicine and Dentistry | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 9 | 10% |
| Unknown | 25 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2015.
All research outputs
#20,248,338
of 22,776,824 outputs
Outputs from NeuroMolecular Medicine
#381
of 447 outputs
Outputs of similar age
#265,468
of 306,604 outputs
Outputs of similar age from NeuroMolecular Medicine
#5
of 9 outputs
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