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The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

Overview of attention for article published in The Journal of Immunology, February 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

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8 news outlets
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8 X users

Citations

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221 Dimensions

Readers on

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246 Mendeley
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Title
The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages
Published in
The Journal of Immunology, February 2015
DOI 10.4049/jimmunol.1401536
Pubmed ID
Authors

Judit Svensson-Arvelund, Ratnesh B Mehta, Robert Lindau, Elahe Mirrasekhian, Heriberto Rodriguez-Martinez, Göran Berg, Gendie E Lash, Maria C Jenmalm, Jan Ernerudh

Abstract

A successful pregnancy requires that the maternal immune system is instructed to a state of tolerance to avoid rejection of the semiallogeneic fetal-placental unit. Although increasing evidence supports that decidual (uterine) macrophages and regulatory T cells (Tregs) are key regulators of fetal tolerance, it is not known how these tolerogenic leukocytes are induced. In this article, we show that the human fetal placenta itself, mainly through trophoblast cells, is able to induce homeostatic M2 macrophages and Tregs. Placental-derived M-CSF and IL-10 induced macrophages that shared the CD14(+)CD163(+)CD206(+)CD209(+) phenotype of decidual macrophages and produced IL-10 and CCL18 but not IL-12 or IL-23. Placental tissue also induced the expansion of CD25(high)CD127(low)Foxp3(+) Tregs in parallel with increased IL-10 production, whereas production of IFN-γ (Th1), IL-13 (Th2), and IL-17 (Th17) was not induced. Tregs expressed the suppressive markers CTLA-4 and CD39, were functionally suppressive, and were induced, in part, by IL-10, TGF-β, and TRAIL. Placental-derived factors also limited excessive Th cell activation, as shown by decreased HLA-DR expression and reduced secretion of Th1-, Th2-, and Th17-associated cytokines. Thus, our data indicate that the fetal placenta has a central role in promoting the homeostatic environment necessary for successful pregnancy. These findings have implications for immune-mediated pregnancy complications, as well as for our general understanding of tissue-induced tolerance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 246 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Canada 1 <1%
Argentina 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 241 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 17%
Student > Bachelor 40 16%
Researcher 30 12%
Student > Master 25 10%
Student > Doctoral Student 20 8%
Other 33 13%
Unknown 56 23%
Readers by discipline Count As %
Medicine and Dentistry 46 19%
Agricultural and Biological Sciences 39 16%
Immunology and Microbiology 39 16%
Biochemistry, Genetics and Molecular Biology 31 13%
Neuroscience 6 2%
Other 19 8%
Unknown 66 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2018.
All research outputs
#604,183
of 23,567,572 outputs
Outputs from The Journal of Immunology
#129
of 27,977 outputs
Outputs of similar age
#9,535
of 389,014 outputs
Outputs of similar age from The Journal of Immunology
#4
of 306 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,977 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,014 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 306 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.